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Abstract
Investigations using immunofluorescence and immunoperoxidase techniques revealed a
gradual, but marked, increase in the numbers of immunoglobulin-secreting cells in
the skin of pigs during the development of lesions of sarcoptic mange. This was followed
by a marked decrease as the lesions regressed. The rise and fall in numbers of these
immunoglobulin-secreting cells were observed in both newborn and older animals as
they developed signs of cutaneous disease. IgG-secreting cells were the major immunoglobulin-containing
cells, followed by IgM- and then IgA-containing cells in the skin of newborn animals.
In older pigs, IgM-secreting cells were most prevalent, followed by IgG- and IgA-secreting
cells. In multiple infestations, immunoglobulin-secreting cells in the dermis showed
very little increase in numbers following the second infestation. Third, fourth and
fifth infestations produced little or no increase.