To assess the differences in blue-yellow perimetry values in patients with an AcrySof Natural intraocular lens (IOL) in 1 eye and a conventional AcrySof IOL in the fellow eye. Cataract and glaucoma clinics of a medical school associated with a public hospital in Brazil. Forty-six patients had bilateral phacoemulsification and implantation of an AcrySof SN60AT IOL (Alcon) in 1 eye and an MA30AC IOL (Alcon) in the fellow eye. Blue-yellow perimetry was performed in both eyes, and the data were analyzed in blinded fashion using the Mann-Whitney U test. No statistically significant differences were observed in short-wavelength automated perimetry (SWAP) values between the 2 IOLs. There was no interference by the yellow filter of the AcrySof Natural IOL in blue-yellow perception as determined by SWAP.