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      Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors

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      Brain Research Reviews

      Elsevier BV

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          Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.

          In newborn mice subcutaneous injectionis of monosodium glutamate induced acute neuronal necrosis in several regions of developing brain including the hypothanamus. As adults, treated animals showed stunted skeletal development, marked obesity, and female sterility. Pathological changes were also found in several organs associated with endocrine function. Studies of food consumption failed to demonstrate hyperphagia to explain the obesity. It is postulated that the aduls syndrome represents a multifacted nueroendocrine disturbance arising from the disruption of developing nueral centers concered in the mediation of endocrine function.
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            Excitatory amino acid transmitters.

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              2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research.

              Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.
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                Author and article information

                Journal
                Brain Research Reviews
                Brain Research Reviews
                Elsevier BV
                01650173
                May 1984
                May 1984
                : 7
                : 2
                : 103-164
                Article
                10.1016/0165-0173(84)90020-1
                © 1984

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