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      Reproductive factors and risk of colorectal polyps in a colonoscopy based study in western Washington State

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          Abstract

          Background

          Oral contraceptives (OC) are associated with a decreased risk of colorectal cancers; however a recent study reported an increased risk of small colorectal adenomas associated with OC use. To determine if these results were replicable in a different study population, we investigated the relationship between OC use and other reproductive factors and risk of colorectal polyps in a case-control study in western Washington.

          Methods

          Study participants were 24–79 year old female enrollees at an integrated health care system in western Washington who were diagnosed as having adenomas (n=299), serrated polyps (n=337), both types of polyps (n= 105) or as polyp-free controls (n=615) through an index colonoscopy and completed a structured interview to collect reproductive history information. Multivariable polytomous logistic regression was used to compare case groups to controls and to each other; odds ratios (OR) and 95% confidence intervals were estimated.

          Results

          There was no association between OC use, duration of use, or recency of use and the risk of either adenomas or serrated polyps [adjusted OR for OC ever use (95% CI) =0.85(0.58–1.23) and 0.96(0.66–1.40), respectively], and associations did not differ by lesion severity within the adenoma or serrated pathways. Further, no associations were observed between other reproductive factors and risk of colorectal polyp subtypes.

          Conclusions

          Our results suggest that reproductive factors, including OC use, are not associated with early colorectal cancer precursor lesions.

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          Author and article information

          Journal
          9100846
          1173
          Cancer Causes Control
          Cancer Causes Control
          Cancer causes & control : CCC
          0957-5243
          1573-7225
          18 March 2017
          15 February 2017
          March 2017
          01 March 2018
          : 28
          : 3
          : 241-246
          Affiliations
          [1 ]Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA
          [2 ]Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA
          [3 ]Kaiser Permanente, Colorado Institute for Health Research, Denver, CO
          [4 ]Group Health Research Institute, Seattle, WA
          [5 ]Department of Pathology, School of Medicine, University of Washington, Seattle, WA
          [6 ]Centre for Public Health Research, Massey University, Wellington; New Zealand
          Author notes
          Corresponding author: Sheetal Hardikar, 1100 Fairview Ave. N., M4-B402, PO Box 19024, Seattle, WA 98109-1024, Tel: 206-667-7140, Fax: 206-667-4787, shardika@ 123456fhcrc.org
          Article
          PMC5411114 PMC5411114 5411114 nihpa852950
          10.1007/s10552-017-0866-2
          5411114
          28205046
          Categories
          Article

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