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      Ultrastructural Changes in Blood Vessels of Perinephritic Hypertensive Dogs

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          Abstract

          Mesenteric arteries and saphenous veins of control and perinephritic hypertensive dogs were studied with light and electron microscopy. 2 weeks after surgery there are ultrastructural changes, both in arteries and veins which are thought to be of hydroelectrolytic origin. These alterations are more marked 7 weeks after surgery and disappear thereafter. There are signs of increased protein synthesis activity in the smooth muscle of the mesenteric arteries, but not of the saphenous veins obtained 7 and 14 weeks after surgery, leading to a progressive hypertrophy of the muscular cells. The connective tissue augmented proportionally. Degeneration of adrenergic nerves in the arteries, accompanied by a parallel decrease in their noradrenaline content, constituted an unexpected finding clearly deserving further study.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1981
          1981
          19 September 2008
          : 18
          : 3
          : 110-119
          Affiliations
          Laboratório de Farmacologia, Faculdade de Medicina, Porto, Portugal
          Article
          158343 Blood Vessels 1981;18:110–119
          10.1159/000158343
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Research Paper

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