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      Ultrastructural Changes in Blood Vessels of Perinephritic Hypertensive Dogs


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          Mesenteric arteries and saphenous veins of control and perinephritic hypertensive dogs were studied with light and electron microscopy. 2 weeks after surgery there are ultrastructural changes, both in arteries and veins which are thought to be of hydroelectrolytic origin. These alterations are more marked 7 weeks after surgery and disappear thereafter. There are signs of increased protein synthesis activity in the smooth muscle of the mesenteric arteries, but not of the saphenous veins obtained 7 and 14 weeks after surgery, leading to a progressive hypertrophy of the muscular cells. The connective tissue augmented proportionally. Degeneration of adrenergic nerves in the arteries, accompanied by a parallel decrease in their noradrenaline content, constituted an unexpected finding clearly deserving further study.

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          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 18
          : 3
          : 110-119
          Laboratório de Farmacologia, Faculdade de Medicina, Porto, Portugal
          158343 Blood Vessels 1981;18:110–119
          © 1981 S. Karger AG, Basel

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          Pages: 10
          Research Paper


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