For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
25
views
0
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      497
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found

      Somatostatin Structure-Activity Studies in the Stomach

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Somatostatin may inhibit gastric exocrine functions independent of blockade of gastrin secretion. In order to further investigate this suppressive effect, somatostatin derivatives were injected to cats bearing a cannulated gastric fistula under pentagastrin stimulation. Results showed that somatostatin-14 was more potent than somatostatin-28 in this particular model. Analogues with substituted residues exhibited a variable spectrum of actions on hormone release and gastric function. A cyclic pentapeptide was deprived of gastric or GH inhibitory properties whereas the related peptide with a benzyl-protecting group on Thr was only devoid of gastric effect. The octapeptide SMS 201-995 was described as a potent inhibitor of gastric secretion in comparison with natural somatostatin in rats and also in humans, but was unable to induce maximal suppression of acid output in the cat model. Differences in gastric effect of different derivatives could be explained on the basis of binding to a selective subset of receptors, since at least two binding sites have been identified in the stomach mucosa. Serial studies with short cyclic somatostatin should help to establish a clear relationship between peptide structure and inhibition of gastric secretion.

          Related collections

          Author and article information

          Journal
          Journal ID (publisher-id): HRE
          Journal ID (nlm-ta): Horm Res Paediatr
          Journal ID (doi): 10.1159/issn.1663-2818
          Title: Hormone Research in Paediatrics
          Publisher: S. Karger AG
          ISBN: 978-3-8055-4809-0
          ISBN: 978-3-318-01960-5
          ISSN (Print): 1663-2818
          ISSN (Electronic): 1663-2826
          Publication date Subscription-year: 1988
          Publication date (Print): 1988
          Publication date (Electronic): 28 November 2008
          Volume: 29
          Issue: 2-3
          Pages: 79-82
          Affiliations
          aDepartment of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK; bDepartamento de Fisiologia Animal, Facultad de Veterinaria, Universidad de Santiago de Compostela, Spain; cDepartamento de Bioquimica, Facultad de Medicina, Universidad de Alcala de Henares, Spain; dPeptide Research, Department of Medicine, Tulane University Medical Center, New Orleans, USA
          Article
          Publisher ID: 180973 Other ID: Horm Res 1988;29:79–82
          DOI: 10.1159/000180973
          PubMed ID: 2900201
          SO-VID: 3fc53e30-a6ee-444c-ae65-2f83b9c9026d
          Copyright © © 1988 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 4
          Categories
          Subject: Somatostatin: Recent Advances in Basic Research and Clinical Applications

          ScienceOpen disciplines: Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Keywords: Gastric acid secretion,Gastric inhibition,Somatostatin,Pepsin secretion,Stomach
          Data availability:
          ScienceOpen disciplines: Endocrinology & Diabetes, Neurology, Nutrition & Dietetics, Sexual medicine, Internal medicine, Pharmacology & Pharmaceutical medicine
          Keywords: Gastric acid secretion, Gastric inhibition, Somatostatin, Pepsin secretion, Stomach

          Comments

          Comment on this article