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Gas chromatography-mass spectrometric analysis of salivary testosterone with reference to diethylstilboestrol-treated prostatic cancer patients
February 1986
February 1986
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Abstract
Testosterone has been quantified in saliva by gas chromatography-mass spectrometry
with selected ion monitoring of the t-butyldimethylsilyl ether (TBDMS) of the oxime
derivative. High specificity of instrumental analysis has been complemented by immunoadsorption
for extraction of the analyte. The sensitivity of the detection is approx. 4 pmol/l
and the precision of quantification is 3.4% CV for a value of 160 pmol/l and 11% for
a value of 25 pmol/l. Female subjects had salivary concentrations of testosterone
of 14-52 pmol/l, while testosterone was not detected in the saliva of prostatic cancer
patients treated with diethylstilboestrol (DES).