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      Immune Response after Vaccination with Recombinant Hepatitis Surface Antigen in Maintenance Hemodialysis Patients and Healthy Controls

      a , a , b , a


      S. Karger AG

      Hemodialysis, Immune response, rDNA-HbsAg, HBV vaccination

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          We evaluated anti-HBs titers 2 months after vaccination with recombinant hepatitis surface antigen (rDNA-HBsAg) in 43 maintenance hemodialysis patients (MHP). Of these, 34 had not undergone hepatitis B virus vaccination previously (NV-MHP) and 9 had shown negative response to vaccination with plasma-derived HBsAg (HEVAC Pasteur; V-MHP). 120 healthy workers from the same hospital undergoing rDNA-HBsAg immunization were used as controls. All low responders (LR) (anti-HBs < 100 mlU/ml) and nonresponders (NR; anti-HBs < 10 mlU/ml) were given a booster dose 3 months after the last dose of vaccine. Seroconversion rates were lower in NV-MHP (52.9%) than in controls (98.4%). V-MHP showed higher seroconversion rates (88.9%) than NV-MHP. In each group, the number of responders (R; anti-HBs ≥ 100 mlU/ml), LRand NR was as follows: controls 101,17,2; NV-MHP 6,12,16; V-MHP 8,0,1. After booster dose, 17/17 controls LR and no NV-MHP LR showed a rise in anti-HBs titers over 100 mlU/ml. Six months after the last dose of vaccine or the booster dose, anti-HBs titer fell under 10 mlU/ml in 4/12 MHP LR and under 100 mlU/ml in 6/14 MHP R. To achieve high seroconversion rates and to avoid the decline of anti-HBs to nonprotective titers in MHP, a booster injection should be made at different dates after the first vaccination.

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          Author and article information

          S. Karger AG
          11 December 2008
          : 61
          : 3
          : 339-340
          aServizio Emodialisi, bDivisione di Medicina Generale, Ospedale di Palmanova, USL no. 8 ‘Bassa Friulana’, Regione Friuli-Venezia Giulia, Palmanova, Italy
          186932 Nephron 1992;61:339–340
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 2
          A Special Issue on Virus Hepatitis and the Kidney

          Cardiovascular Medicine, Nephrology

          HBV vaccination, rDNA-HbsAg, Immune response, Hemodialysis


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