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      Randomized Trials are Deeply Offensive

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      The American Journal of Bioethics
      Informa UK Limited

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          Most cited references5

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          Equipoise and the dilemma of randomized clinical trials.

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            Of mice but not men. Problems of the randomized clinical trial.

            S. Hellman (1991)
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              Outcomes for patients with the same disease treated inside and outside of randomized trials: a systematic review and meta-analysis.

              It is unclear whether participation in a randomized controlled trial (RCT), irrespective of assigned treatment, is harmful or beneficial to participants. We compared outcomes for patients with the same diagnoses who did ("insiders") and did not ("outsiders") enter RCTs, without regard to the specific therapies received for their respective diagnoses.
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                Author and article information

                Journal
                The American Journal of Bioethics
                The American Journal of Bioethics
                Informa UK Limited
                1526-5161
                1536-0075
                January 02 2020
                January 02 2020
                January 02 2020
                : 20
                : 1
                : 3-5
                Affiliations
                [1 ] Children’s Mercy Bioethics Center
                Article
                10.1080/15265161.2019.1695487
                3fdc0b04-134b-46ac-803e-b46b3809c86d
                © 2020
                History

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