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      In situ FTIR spectroscopic monitoring of electrochemically controlled organic reactions in a recycle reactor

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          Abstract

          An electrochemical reactor coupled with a recycle loop through a transmission FTIR cell allows continuous monitoring of reaction progress.

          Abstract

          An electrochemical cell coupled with a recycle loop through a transmission FTIR cell is employed in studies of two free radical organic reactions, the oxidation of allylic alcohols and the trifluoromethylation of heteroarenes. Rapid mixing through the recycle loop allows continuous monitoring of reaction progress. Electrochemical generation of free radicals allows their controlled mediation into the reaction mixture for more efficient reaction. Kinetic profiles provide mechanistic insight into reactions under electrochemical control.

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          Reaction progress kinetic analysis: a powerful methodology for mechanistic studies of complex catalytic reactions.

          Reaction progress kinetic analysis to obtain a comprehensive picture of complex catalytic reaction behavior is described. This methodology employs in situ measurements and simple manipulations to construct a series of graphical rate equations that enable analysis of the reaction to be accomplished from a minimal number of experiments. Such an analysis helps to describe the driving forces of a reaction and may be used to help distinguish between different proposed mechanistic models. This Review describes the procedure for undertaking such analysis for any new reaction under study.
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            Synthetic Applications of Anodic Electrochemistry

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              Total Synthesis of Dixiamycin B by Electrochemical Oxidation

              N–N-linked dimeric indole alkaloids represent an unexplored class of natural products for which chemical synthesis has no practical solution. To meet this challenge, an electrochemical oxidative dimerization method was developed, which was applied as the pivotal step of the first total synthesis of dixiamycin B. This method is also general for N–N dimerization of substituted carbazoles and β-carbolines, providing entry into seldom explored chemical space.
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                Author and article information

                Journal
                RCEEBW
                Reaction Chemistry & Engineering
                React. Chem. Eng.
                Royal Society of Chemistry (RSC)
                2058-9883
                2016
                2016
                : 1
                : 1
                : 90-95
                Affiliations
                [1 ]Department of Chemistry
                [2 ]The Scripps Research Institute
                [3 ]La Jolla
                [4 ]USA
                Article
                10.1039/C5RE00050E
                4826070
                27069673
                3fe6b7b6-d4f8-4939-979b-c8b65ffc6491
                © 2016
                History

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