1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Pulsatile insulin release: role of cytoplasmic Ca2+ oscillations.

      1 , ,

      Diabetes & metabolism

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Oscillations of plasma insulin are essential for the hypoglycaemic effect of the hormone. Disturbance and partial loss of these oscillations occur during the development of Type 2 diabetes, in association with down-regulation of insulin receptors and insulin resistance. Oscillations with a frequency similar to that of plasma insulin have been observed in the cytoplasmic Ca2+ concentration ([Ca2+]i) of pancreatic beta cells, indicating that the ion plays a role in generating insulin pulses. Studies of individual islets have revealed that oscillations of [Ca2+]i and insulin release are synchronous. However, insulin release is also pulsatile under conditions in which [Ca2+]i is stable. These results support the notion that variations in the ATP/ADP ratio are sufficient to induce pulsatile insulin release. Under physiological conditions, this pulsatility may depend on the synergistic effects of ATP/ADP and [Ca2+]i oscillations.

          Related collections

          Author and article information

          Journal
          Diabetes Metab
          Diabetes & metabolism
          1262-3636
          1262-3636
          Feb 1998
          : 24
          : 1
          Affiliations
          [1 ] Department of Medical Cell Biology, Biomedicum, Uppsala, Sweden. Peter.Bergsten@medcellbiol.uu.se
          Article
          MDOI-DM-02-1998-24-1-1262-3636-101019-ART82
          9534008

          Comments

          Comment on this article