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      14-Thienyl methylene matrine (YYJ18), the derivative from matrine, induces apoptosis of human nasopharyngeal carcinoma cells by targeting MAPK and PI3K/Akt pathways in vitro.

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          Abstract

          Nasopharyngeal carcinoma (NPC) is a distinctive type of head and neck cancer with the highest incidence in South China. Previous studies have proved that matrine, a main alkaloid isolated from Sophora flavescens Ait, has antitumor activity against NPC. However, the effect is not so pronounced and the underlying mechanism remains largely unclear. Here we investigated whether 14-thienyl methylene matrine (YYJ18) that was derived from matrine could exert more effective suppression activity on NPC, along with the underlying mechanism.

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          Author and article information

          Journal
          Cell. Physiol. Biochem.
          Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
          1421-9778
          1015-8987
          2014
          : 33
          : 5
          Affiliations
          [1 ] Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P.R.China.
          Article
          000358712
          10.1159/000358712
          24854624
          400cd7a8-a0ca-4ed8-8e52-cca7ab1fe74c
          © 2014 S. Karger AG, Basel.

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