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      Severe multifactorial hyponatremia in a lung transplantated patient: case report Translated title: Hiponatremia severa multifactorial en un paciente de trasplante de pulmón: reporte de caso

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          Abstract

          Abstract Hyponatremia is a common electrolyte disorder in clinical practice. It is sometimes difficult to identify the causes. We present a case about severe multifactorial hyponatremia in a patient with a history of lung transplantation on regular tacrolimus who complained of back pain being treated with tramadol. Possible causes are analyzed and discussed.

          Translated abstract

          Resumen La hiponatremia es una alteración habitual en la práctica clínica. En algunas ocasiones es difícil identificar la causa. Presentamos el caso de una hiponatremia multifactorial en un paciente con historia de trasplante pulmonar en tratamiento con tacrolimus que inició tratamiento con tramadol debido a una lumbalgia. Se analizan y discuten las posibles causas.

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          A review of drug-induced hyponatremia.

          Hyponatremia (defined as a serum sodium level < 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients. Certain drugs (eg, diuretics, antidepressants, and antiepileptics) have been implicated as established causes of either asymptomatic or symptomatic hyponatremia. However, hyponatremia occasionally may develop in the course of treatment with drugs used in everyday clinical practice (eg, newer antihypertensive agents, antibiotics, and proton pump inhibitors). Physicians may not always give proper attention in time to undesirable drug-induced hyponatremia. Effective clinical management can be handled through awareness of the adverse effect of certain pharmaceutical compounds on serum sodium levels. Here, we review clinical information about the incidence of hyponatremia associated with specific drug treatment and discuss the underlying pathophysiologic mechanisms.
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            Hyponatraemia in elderly psychiatric patients treated with Selective Serotonin Reuptake Inhibitors and venlafaxine: a retrospective controlled study in an inpatient unit.

            To determine the prevalence of hyponatraemia associated with selective serotonin reuptake inhibitor (SSRI) and venlafaxine use in elderly patients compared to that in elderly patients not prescribed these drugs, while controlling for age, sex, depression status and illnesses or prescribed medications also associated with hyponatraemia. Design and setting Retrospective controlled analysis in a 36-bed inpatient unit for elderly psychiatric patients in Melbourne. Inpatients (199) with a mean age of 74.2 years of whom 74 were prescribed an SSRI or venlafaxine. Patients on SSRIs or venlafaxine were 5.6 times as likely as patients not so treated to have hyponatraemia. Thirty-nine percent of patients on an SSRI or venlafaxine had hyponatraemia compared with 10% of controls. Ten of the 14 patients on venlafaxine were hyponatraemic. Controlling for thiazide status did not reduce the odds of these patients having hyponatraemia and taking an SSRI or venlafaxine was still strongly associated with hyponatraemia after also controlling for age, sex, and depression status, consumption of other drugs potentially causative of hyponatraemia and medical illness severity (Odds Ratio (OR) 3.5, p = 0.008). SSRI and venlafaxine use is strongly associated with the presence of hyponatraemia in a population of elderly psychiatric inpatients and the association is not due to confounding by age, sex, depression status, medical illness severity or consumption of other drugs. Elderly patients on SSRIs or venlfaxine should have sodium levels checked before and after commencement of antidepressant treatment. Copyright 2002 John Wiley & Sons, Ltd.
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              Epidemiology, Pathophysiology, and Management of Hyponatremic Encephalopathy

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                rca
                Revista Colombiana de Anestesiología
                Rev. colomb. anestesiol.
                SCARE-Sociedad Colombiana de Anestesiología y Reanimación (Bogotá, Cundinamarca, Colombia )
                0120-3347
                September 2018
                : 46
                : 3
                : 250-252
                Affiliations
                [1] Madrid orgnameCritical Care and Pain at Hospital Puerta de Hierro Majadahonda orgdiv1Department of Anesthesiology España
                Article
                S0120-33472018000300250
                10.1097/cj9.0000000000000052
                4013460a-ea73-4893-86d4-617691e53605

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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                Figures: 0, Tables: 0, Equations: 0, References: 16, Pages: 3
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                SciELO Colombia


                Hiponatremia,Tacrolimus,Tramadol,Trasplante de Pulmón,Síndrome de Secreción Inadecuada de ADH,Hyponatremia,Lung TransplantationInappropriate ADH Syndrome

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