26
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Comparison of human adult and fetal expression and identification of 535 housekeeping/maintenance genes.

      Physiological Genomics
      Adult, Brain Chemistry, Embryonic and Fetal Development, genetics, Female, Gene Expression Profiling, Genes, Humans, Kidney, chemistry, embryology, Liver, Lung, Male, Myocardium, Oligonucleotide Array Sequence Analysis, Organ Specificity, Pancreas, RNA, Messenger, analysis, Reference Values, Testis, Uterus

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Gene expression levels of about 7,000 genes were measured in 11 different human adult and fetal tissues using high-density oligonucleotide arrays to identify genes involved in cellular maintenance. The tissues share a set of 535 transcripts that are turned on early in fetal development and stay on throughout adulthood. Because our goal was to identify genes that are involved in maintaining cellular function in normal individuals, we minimized the effect of individual variation by screening mRNA pooled from many individuals. This information is useful for establishing average expression levels in normal individuals. Additionally, we identified transcripts uniquely expressed in each of the 11 tissues.

          Related collections

          Author and article information

          Comments

          Comment on this article