A description of 93 cases of angiokeratoma [Mibelli (3 cases), Fordyce (13 cases), circumscriptum naeviformis (12 cases) and solitary (65 cases)], confirmed histologically and observed during the last 30 years (1955-1985) in the Department of Medicine and Surgery of the School of Medicine of the University of Granada is presented. We carry out a detailed histological and ultrastructural study.