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      Rare and common variants: twenty arguments.

      Nature reviews. Genetics
      Alleles, Animals, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Models, Genetic

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          Abstract

          Genome-wide association studies have greatly improved our understanding of the genetic basis of disease risk. The fact that they tend not to identify more than a fraction of the specific causal loci has led to divergence of opinion over whether most of the variance is hidden as numerous rare variants of large effect or as common variants of very small effect. Here I review 20 arguments for and against each of these models of the genetic basis of complex traits and conclude that both classes of effect can be readily reconciled.

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          Author and article information

          Journal
          22251874
          4408201
          10.1038/nrg3118

          Chemistry
          Alleles,Animals,Genetic Predisposition to Disease,Genetic Variation,Genome-Wide Association Study,Humans,Models, Genetic

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