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      The influence of oxygen and pressure on keratinocytes

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      British Journal of Pharmacy
      University of Huddersfield Press

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          Abstract

          This study aims to elucidate the respective effects of normobaric hyperoxygenationand hyperbaric pressurisation on key re-epithelialisation processes in woundhealing. Cultured human keratinocytes exposed to intermittent normobaric hyperoxygenationexhibited enhanced cellularmigration marked by a significant decline in E-cadherin expression. Keratinocyteproliferation, cellular metabolic activity, as well as IL-6 and IL-8 releasewere also significantly reduced. These changes were not observed with hyperbaricpressurisation alone. Moreover, cellular differentiation was not altered undernormobaric hyperoxygenation or hyperbaric pressurisation. Thus, we concludethat hyperoxygenation differentially modulates key cellular processes in re-epithelialisation.Oxygenation, but not pressurisation, appears to be the predominant factor modulatingkeratinocyte migration and proliferation. These findings argue for an alternativetreatment modality to hyperbaric oxygenation for wound healing, focused on enhancingtissue oxygenation without administering hyperbaric pressures.

          Author and article information

          Journal
          British Journal of Pharmacy
          University of Huddersfield Press
          2058-8356
          April 2 2019
          April 2 2019
          : 4
          : 1
          Article
          10.5920/bjpharm.598
          404f3e39-1f32-4c16-9652-b14f9045329f
          © 2019

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

          History

          Medicine,Pharmacology & Pharmaceutical medicine,Health & Social care
          Medicine, Pharmacology & Pharmaceutical medicine, Health & Social care

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