21
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Molecular imaging of cardiac remodelling after myocardial infarction

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Myocardial infarction and subsequent heart failure is a major health burden associated with significant mortality and morbidity in western societies. The ability of cardiac tissue to recover after myocardial infarction is affected by numerous complex cellular and molecular pathways. Unbalance or failure of these pathways can lead to adverse remodelling of the heart and poor prognosis. Current clinical cardiac imaging modalities assess anatomy, perfusion, function, and viability of the myocardium, yet do not offer any insight into the specific molecular pathways involved in the repair process. Novel imaging techniques allow visualisation of these molecular processes and may have significant diagnostic and prognostic values, which could aid clinical management. Single photon-emission tomography, positron-emission tomography, and magnetic resonance imaging are used to visualise various aspects of these molecular processes. Imaging probes are usually attached to radioisotopes or paramagnetic nanoparticles to specifically target biological processes such as: apoptosis, necrosis, inflammation, angiogenesis, and scar formation. Although the results from preclinical studies are promising, translating this work to a clinical environment in a valuable and cost-effective way is extremely challenging. Extensive evaluation evidence of diagnostic and prognostic values in multi-centre clinical trials is still required.

          Related collections

          Most cited references122

          • Record: found
          • Abstract: found
          • Article: not found

          The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge.

          The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over the last two decades in developed countries, but mortality from STEMI despite widespread access to reperfusion therapy is still substantial as is the development of heart failure, particularly among an expanding older population. In developing countries, the incidence of STEMI is increasing and interventional reperfusion is often not available. We here review the pathophysiology of acute myocardial infarction and reperfusion, notably the temporal and spatial evolution of ischaemic and reperfusion injury, the different modes of cell death, and the resulting coronary microvascular dysfunction. We then go on to briefly characterize the cardioprotective phenomena of ischaemic preconditioning, ischaemic postconditioning, and remote ischaemic conditioning and their underlying signal transduction pathways. We discuss in detail the attempts to translate conditioning strategies and drug therapy into the clinical setting. Most attempts have failed so far to reduce infarct size and improve clinical outcomes in STEMI patients, and we discuss potential reasons for such failure. Currently, it appears that remote ischaemic conditioning and a few drugs (atrial natriuretic peptide, exenatide, metoprolol, and esmolol) reduce infarct size, but studies with clinical outcome as primary endpoint are still underway.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology.

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Myocardial reperfusion: a double-edged sword?

                Bookmark

                Author and article information

                Contributors
                +44 077 608 771 35 , begona.lavin_plaza@kcl.ac.uk
                Journal
                Basic Res Cardiol
                Basic Res. Cardiol
                Basic Research in Cardiology
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0300-8428
                1435-1803
                17 January 2018
                17 January 2018
                2018
                : 113
                : 2
                : 10
                Affiliations
                [1 ]ISNI 0000 0001 2322 6764, GRID grid.13097.3c, GKT School of Medicine, , King’s College London, ; London, UK
                [2 ]GRID grid.425213.3, School of Biomedical Engineering and Imaging Sciences, King’s College London, , St. Thomas Hospital, ; 4th Floor, Lambeth Wing, London, SE1 7EH UK
                [3 ]ISNI 0000 0001 2322 6764, GRID grid.13097.3c, School of Cardiovascular Medicine and Sciences, , King’s College London, ; London, UK
                [4 ]ISNI 0000 0001 2322 6764, GRID grid.13097.3c, The British Heart Foundation Centre of Excellence, , King’s College London, ; London, UK
                [5 ]ISNI 0000 0001 2157 0406, GRID grid.7870.8, Escuela de Ingeniera, , Pontificia Universidad Catolica de Chile, ; Santiago, Chile
                Author information
                http://orcid.org/0000-0003-4671-1089
                Article
                668
                10.1007/s00395-018-0668-z
                5772148
                29344827
                405f5131-0f34-4ffc-93c9-ae02448a50a1
                © The Author(s) 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 1 June 2017
                : 17 November 2017
                : 8 January 2018
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100000266, Engineering and Physical Sciences Research Council;
                Award ID: EP/P001009/1
                Award Recipient :
                Funded by: Engineering and Physical Sciences Research Council (GB)
                Award ID: EP/P007619/1
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/501100000274, British Heart Foundation;
                Award ID: RG/12/1/29262
                Award Recipient :
                Funded by: FONDECYT
                Award ID: 1161051
                Award Recipient :
                Funded by: Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC
                Award ID: WT 088641/Z/09/Z
                Award Recipient :
                Funded by: Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust
                Categories
                Review
                Custom metadata
                © Springer-Verlag GmbH Germany, part of Springer Nature 2018

                Cardiovascular Medicine
                myocardial infarction,cardiac remodelling,cardiovascular imaging,mri
                Cardiovascular Medicine
                myocardial infarction, cardiac remodelling, cardiovascular imaging, mri

                Comments

                Comment on this article