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      Gut Microbiome and Depression: How Microbes Affect the Way We Think

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          Abstract

          The gut microbiome serves an important role in the human body. Reportedly, one of the benefits of these microflora is on mental health. Once established, food and other dietary sources that enhance quality microbiome content in our gastrointestinal system will be a significant consideration in individuals’ day to day lives. This literature review conducted a PubMed search for studies about the gut microbiome and its relation to depression. In using several Medical Subject Heading (MeSH) keywords, relevant literature was selected. A total of 26 articles were selected after applying the inclusion and exclusion criteria, and after checking the articles’ accessibility. This literature would like to establish the role of the gut microbiome in depression. This study's findings showed that there is a strong association of microbiome function to mental well-being.

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          Most cited references15

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          Food and mood: how do diet and nutrition affect mental wellbeing?

          Poor nutrition may be a causal factor in the experience of low mood, and improving diet may help to protect not only the physical health but also the mental health of the population, say Joseph Firth and colleagues
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            Effects of obesity on depression: A role for inflammation and the gut microbiota

            Depression is a mental disorder associated with environmental, genetic and psychological factors. Recent studies indicate that chronic neuro-inflammation may affect brain physiology and alter mood and behavior. Consumption of a high-fat diet leads to obesity and chronic systemic inflammation. The gut microbiota mediates many effects of a high-fat diet on human physiology and may also influence the mood and behavior of the host. We review here recent studies suggesting the existence of a link between obesity, the gut microbiota and depression, focusing on the mechanisms underlying the effects of a high-fat diet on chronic inflammation and brain physiology. This body of research suggests that modulating the composition of the gut microbiota using prebiotics and probiotics may produce beneficial effects on anxiety and depression.
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              A gut (microbiome) feeling about the brain.

              There is an increasing realization that the microorganisms which reside within our gut form part of a complex multidirectional communication network with the brain known as the microbiome-gut-brain axis. In this review, we focus on recent findings which support a role for this axis in modulating neurodevelopment and behavior.
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                Author and article information

                Journal
                Cureus
                Cureus
                2168-8184
                Cureus
                Cureus (Palo Alto (CA) )
                2168-8184
                23 August 2020
                August 2020
                : 12
                : 8
                : e9966
                Affiliations
                [1 ] Psychiatry, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA
                Author notes
                Article
                10.7759/cureus.9966
                7510518
                32983670
                4071a1dd-abc9-48d7-8abc-30d7ceefb41b
                Copyright © 2020, Limbana et al.

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 9 August 2020
                : 22 August 2020
                Categories
                Family/General Practice
                Psychiatry
                Gastroenterology

                gastrointestinal microbiome,depression,gut microbiome,gastrointestinal microbiome and depression,gut microflora,bacterial commensals,gut microbiome and mental health,intestinal microbiota,intestinal microbiota and depression,bacterial commensals and depression

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