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      Exceptional Renal Metastasis from Adenoid Cystic Carcinoma of the Nasal Cavity and Literature Review

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          Abstract

          Adenoid cystic carcinoma (ACC) is a rare malignant cancer that arises from secretory glands. Slow growth, perineural invasion, and late recurrences are the main characteristics of ACC. Only few cases of kidney metastases from ACC have been reported in the literature. We report here the case of a 66-year-old female patient who presented with bilateral renal metastases from ACC of the nasal cavity, detected 14 years after treatment of primary tumor and 6 years after metastasectomy of lung metastases. Histological examination confirmed diagnosis and the patient was treated with systemic chemotherapy. Radiological evaluation showed stability of the disease. However, a progression with occurrence of metastases in other sites (lung and bones) has been observed after 7 months. She is still receiving second-line chemotherapy. To the best of our knowledge, this is the second case of kidney metastases from ACC of the nasal cavity.

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          Most cited references6

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          Adenoid cystic carcinoma of the head and neck--An update.

          This article provides an update on the current understanding of adenoid cystic carcinoma of the head and neck, including a review of its epidemiology, clinical behavior, pathology, molecular biology, diagnostic workup, treatment and prognosis. Adenoid cystic carcinoma is an uncommon salivary gland tumor that may arise in a wide variety of anatomical sites in the head and neck, often with an advanced stage at diagnosis. The clinical course is characterized by very late recurrences; consequently, clinical follow-up should extend at least >15 years. The optimal treatment is generally considered to be surgery with postoperative radiotherapy to optimize local disease control. Much effort has been invested into understanding the tumor's molecular biological processes, aiming to identify patients at high risk of recurrence, in hopes that they could benefit from other, still unproven treatment modalities such as chemotherapy or biological therapy.
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            Adenoid cystic carcinoma of the head and neck: a review.

            This purpose of this article is to review and provide an update of current publications on the evaluation and management of adenoid cystic carcinoma. Adenoid cystic carcinoma is an uncommon salivary gland malignancy that presents insidiously and is generally advanced when diagnosed. Current effective treatment modalities include surgery and irradiation, but locoregional recurrences are frequent and may present as early as 2 years. Patients survive with recurrent and metastatic disease for several years despite not being offered any treatment. Molecular analysis of the tumors is being undertaken, with optimistic results capable of selecting high-risk patients who may benefit from adjuvant treatment such as chemotherapy Little progress has been made in advancing "curative" treatment of adenoid cystic carcinoma of the head and neck. The disease is said to have a fatal outcome. The time is now opportune for a multicenter, randomized, controlled trial to identify patients who would benefit from adjuvant radiotherapy and/or chemotherapy in the control of locoregional recurrences and the prevention of distant metastases.
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              Adenoid cystic carcinoma: A review of recent advances, molecular targets, and clinical trials

              Abstract Background Adenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. In this study, recent advances in molecular characterization and in therapeutics are reviewed. Methods A search of articles in PubMed and of abstracts from national meetings was performed regarding ACC. Results Recent genetic analyses found that recurrent chromosome 6:9 translocations in ACC generate an MYB:NFIB gene fusion resulting in overexpression of the MYB oncoprotein. Several other frequent mutations are recently published that may be relevant for drug development. Several trials of targeted drugs are reviewed. Some agents delay tumor progression, but tumor responses remain rare. Conclusion ACCs have a characteristic chromosomal translocation, but also frequently pick up additional mutations. Clinical research is limited by the rarity and slow growth of ACC. Several ongoing trials are testing agents that inhibit fibroblast growth factor receptor signaling or other signaling pathways. Novel treatments based on the recently sequenced tumor genome are under development. © 2015 The Authors Head & Neck Published by Wiley Periodicals, Inc. 38: 620–627, 2016
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                Author and article information

                Journal
                J Kidney Cancer VHL
                J Kidney Cancer VHL
                JKCVHL
                Journal of Kidney Cancer and VHL
                Codon Publications
                2203-5826
                23 September 2021
                2021
                : 8
                : 3
                : 19-21
                Affiliations
                [1 ]Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia;
                [2 ]Department of Pathology, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia;
                [3 ]Department of Radiology, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia
                Author notes
                Author for correspondence: Maissa Lajnef, Department of Medical Oncology, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia. E-mail: lajnefmayssa@ 123456hotmail.com
                Article
                JKCVHL-8-019
                10.15586/jkcvhl.v8i3.173
                8476345
                407d5fef-9636-469f-8352-77b1969c07d8
                Copyright: Jihene Feki, et al.

                This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0

                History
                : 07 January 2021
                : 01 August 2021
                Categories
                Case Report

                adenoid cystic,carcinoma,nasal cavity,kidney,renal metastases

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