Introduction
Coronavirus disease 2019 (COVID-19) outbreak requires that endocrinologists from all
over Europe move on, even more, to the first line of care of our patients, also in
collaboration with other physicians such as those in internal medicine and emergency
units. This will preserve the health status and prevent the adverse COVID-19-related
outcomes in people affected by different endocrine diseases. People with diabetes
in particular are among those in high-risk categories who can have serious illness
if they get the virus, according to the data published so far from the Chinese researchers,
but other endocrine diseases such as obesity, malnutrition, and adrenal insufficiency
may also be impacted by COVID-19. Therefore, since the responsibilities of endocrinologists
worldwide due to the current COVID-19 outbreak are not minor we have been appointed
by the European Society of Endocrinology (ESE) to write the current statement in order
to support the ESE members and the whole endocrine community in this critical situation.
In addition, endocrinologists, as any other healthcare worker under the current COVID-19
outbreak, will need to self-protect from this viral disease, which is demonstrating
to have a very high disseminating and devastating capacity. We urge Health Authorities
to provide adequate protection to the whole workforce of health professionals and
to consistently test for COVID-19 the exposed personnel. A decrease in the number
of healthcare professionals available for active medical practice in case they contract
the disease as it is happening in certain countries, is itself, a threat for the healthcare
system and the well-being of our patients.
The virus seems to have spread from infected animals and human-to-human transmission
is now more than evident, with a high suspicion that non-symptomatic individuals act
as the major vectors. It spreads like any other respiratory infectious disease, through
contaminated air-droplets that come out of the mouth of infected persons when talking,
coughing, or sneezing. The virus can survive in the environment from a few hours to
a few days, depending on surfaces and environmental conditions, and touching affected
surfaces. The mouth, nose, and ocular mucosa appears to be the major way of transmission.
Symptoms of COVID-19 infection
General symptoms are relatively nonspecific and similar to other common viral infections
targeting the respiratory system, and include fever, cough, myalgia, and shortness
of breath. The clinical spectrum of the virus ranges from mild disease with nonspecific
signs and symptoms of acute respiratory illness, to severe pneumonia with respiratory
failure and septic shock. Possibly, an overreaction of the immune system leading to
an autoimmune aggression of the lungs could be involved in the most severe cases of
acute distress respiratory syndrome. There have also been reports of asymptomatic
infection and research in this matter is currently ongoing worldwide to elucidate
the real prevalence of the disease and the true relative mortality ratio.
COVID-19 infection and diabetes mellitus
Increased risk of morbidity and mortality in patients with diabetes regarding COVID-19
infection
Older adults and those with serious chronic medical conditions like heart disease,
lung disease, and diabetes are at the highest risk for complications from COVID-19
infection. Chronic hyperglycemia negatively affects immune function and increases
the risk of morbidity and mortality due to any infection and is associated to organic
complications. This is also the case for COVID-19 infection [1]. During the Influenza
A (H1N1) pandemic, the presence of diabetes tripled the risk of hospitalization and
quadrupled the risk of ICU admission once hospitalized. Among COVID-19 mortality cases
in Wuhan, China, major associated comorbidities included hypertension (53.8%), diabetes
(42.3%), previous heart disease (19.2%), and cerebral infarction (15.4%) [2]. In addition,
as for seasonal influenza, new data regarding COVID-19 indicate that the infection
potentiates myocardial damage and identifies underlying heart disorders as a new risk
factor for severe complications and worsening of prognosis [3].
Among the confirmed COVID-19 cases in China by Feb 11, 2020, the overall mortality
reported is 2.3% [4]. This data refers mostly to hospitalized patients [4, 5]. Among
persons with no underlying medical conditions, the reported mortality in China is
0.9%.
There is a lack of data regarding the number of non-symptomatic cases, as in most
countries universal microbiological screening has not been performed. It is presumed
that the prevalence of the infection is probably high or very high in the community,
thus leading to an overestimation of the prevalence of case fatality. However, mortality
is strongly increased with the presence of comorbid diseases, including previous cardiovascular
disease (10.5%), diabetes (7.3%), chronic respiratory disease, hypertension, and cancer,
each at 6%. Among 60-year-old people and older, mortality has been reported to be
14.8% in those >80 years, 8% for those between 70 and 79 years and 3.6% in the group
of 60–69 years. Compared with non-ICU patients, critically ill patients are older
(median age 66 vs. 51 years) and have more previous comorbidities (72% vs. 37%) [6].
Worldwide mortality rates may vary by region, but this information is not yet consistently
available and comparable, as public health policies applied and health registers used
in every region of the world are not homogeneous.
What people with diabetes should do to prevent infection by COVID-19
Social distancing as well as home confinement of the whole population are now widely
adopted in many countries in Europe and worldwide as measures hopefully effective
in contrast to the spread of infection. We recommend that due to the increased dangers
of developing COVID-19, persons with diabetes should strictly adhere to these preventive
measures and adopt them also within their homes in order to avoid being in contact
with their relatives. Therefore, under these circumstances, it is recommended that
people with diabetes try to plan ahead of time what to do in case they get ill. It
is important to maintain a good glycemic control, because it might help reduce the
risk of infection itself and may also modulate the severity of the clinical expression
of the disease.
Contact with healthcare providers, such as endocrinologists in the case of type 1
diabetes, and including also internal medicine specialists and general practitioners
for type 2 diabetes patients may be advisable. However, routine appointments in person
are not recommended for people with diabetes, as they should avoid crowds (waiting
rooms). Therefore, we recommend phone calls, video calls, and emails as the main way
for patients to keep in touch with their healthcare provider team, in order to guarantee
an optimal control of the disease. Moreover, it is advised to ensure adequate stock
of medications and supplies for monitoring blood glucose during the period of home
confinement.
What people with diabetes should do if they are infected by COVID-19
People with diabetes who are infected with COVID-19 may experience a deterioration
of glycemic control during the illness, like in any other infectious episodes. Implementation
of “Sick day rules” is therefore mandatory to overcome potential diabetes decompensation.
Contacting the healthcare provider team by telephone, email, or videoconference is
also mandatory in case of possible symptoms of COVID-19 infection in order to seek
advice concerning the measures to avoid risk of deterioration of diabetes control
or the possibility to be referred to another specialist (pneumologist or infectious
disease doctor) or in the Emergency Services of the referral hospital to avoid the
most serious systemic complication of the viral infection itself.
COVID-19 and other endocrine and metabolic disorders
Obesity
There is a general lack of data regarding the impact of COVID -19 in people suffering
from obesity. However, as for what is currently being the experience in some hospitals
in Spain, cases of young people in which severe obesity is present may evolve toward
destructive alveolitis with respiratory failure and death (Puig-Domingo M, personal
experience). There is no current explanation for this clinical presentation, although
it is well known that severe obesity is associated to sleep-apnea syndrome, as well
as to surfactant dysfunction, which may contribute to a worse scenario in the case
of COVID-19 infection. Also, deterioration of glycemic control is associated with
an impairment of ventilatory function and thus may contribute to a worse prognosis
in these patients. In addition, type 2 diabetes and obesity may concur in a given
patient, which typically is also frequently accompanied by an age >65. In summary,
these patients may be at a higher risk of impaired outcomes in the case of COVID-19
infection.
Undernourishment
Regarding undernourished subjects, COVID-19 infection is associated to a high risk
of malnutrition development, mostly related to increased requirements and the presence
of a severe acute inflammatory status. These patients show also a hyporexic state,
thus contributing to a negative nutritional balance. Estimated nutritional requirements
are 25–30 kcal/kg of weight and 1.5 g protein/kg/day [7]. A nutrient dense diet is
recommended in hospitalized cases including high protein supplements (2–3 intakes
per day) containing at least 18 g of protein per intake. Adequate supplementation
of vitamin D is recommended particularly in areas with large known prevalence of hypovitaminosis
D and due to the decreased sun exposure [8, 9]. If nutritional requirements are not
met, complementary or complete enteral feeding may be required, and in case that enteral
feeding may not be possible due to inadequate gastrointestinal tolerance, the patient
should be put on parenteral nutrition. COVID-19 patients’ outcome is expected to improve
with nutritional support [10].
Adrenal insufficiency
Adrenal insufficiency is a chronic condition of lack of cortisol production. Live-long
replacement treatment aiming to mimic physiologic plasma cortisol concentrations is
not easy for these patients.
Based on current data, there is no evidence that patients with adrenal insufficiency
are at increased risk of contracting COVID-19. However, it is known that patients
with Addison’s disease (primary adrenal insufficiency) and congenital adrenal hyperplasia
have a slightly increased overall risk of catching infections. Moreover, primary adrenal
insufficiency is associated to an impaired natural immunity function with a defective
action of neutrophils and natural killer cells [11]. This may explain, in part, this
slightly increased rate of infectious diseases in these patients, as well as an overall
increased mortality. This latter could also be accounted by an insufficient compensatory
increase of the hydrocortisone dosage at the time of the beginning of an episode of
infection. For all these reasons, patients with adrenal insufficiency may be at higher
risk of medical complications and eventually at increased mortality risk in the case
of COVID-19 infection. So far, there are no reported data on the outcomes of COVID-19
infection in adrenal insufficient subjects.
In the case of suspicion of COVID-19, a prompt modification of the replacement treatment
as indicated for the “Sick days” should be established when minor symptoms appear.
This means in the first instance to at least double the usual doses of glucocorticoid
replacement, to avoid adrenal crisis. In addition, patients are also recommended to
have sufficient stock at home of steroid pills and injections in order to maintain
the social confinement that is required in most of the countries for impeding the
COVID-19 outbreak spread.
Actions to be taken if infection by COVID-19 is suspected
If a person with endocrine and metabolic diseases has fever with cough or trouble
breathing and may have been exposed to COVID-19 (if living in or visited a country
affected in the 14 days before getting sick, or if having been around a person who
may have had the virus), a call to the physician or nurse for advice should be made.
Some countries have set up COVID-19 phone lines for the public. The personnel in charge
of these phone lines will prioritize arrangements, if needed, regarding what should
be the next step in the healthcare protocol. If the person is advised to go to the
hospital, it is recommended to put on a face mask. In countries with explosive outbreak,
most of the people have already bought a face mask by their own initiative. Fluid
samples taken from the nose or throat will be used for microbiologic diagnosis. There
is currently no specific treatment for COVID-19, but since the majority of cases are
mild, only a limited amount of people will require hospitalization for supportive
care. However, in most of the countries in which the outbreak has been declared and
recognized, particularly in China, the Northern regions of Italy, Iran, and Spain,
the situation has been very challenging and the requirement of hospitalization has
led national health systems to the limit of their capacities [12].
What to do in case of confinement at home?
Individuals and families affected or suspected to be affected by COVID-19 that stay
at home should follow proper measures for infection prevention and control. Management
should focus on prevention of transmission to others and monitoring for clinical deterioration,
which may prompt hospitalization. Affected persons should be placed in a well-ventilated
single room, while household members should stay in a different room or, if that is
not possible, maintain a distance of at least one meter from the person affected (e.g.,
sleep in a separate bed) and perform hand hygiene (washing hands with soap and water)
after any type of contact with the affected person or their immediate environment.
When washing hands, it is preferable to use disposable paper towels to dry them. If
these are not available, clean cloth towels should be used and replaced when wet.
To contain respiratory secretions, a medical mask should be provided to the person
affected and worn as much as possible. Individuals who cannot tolerate a medical mask
should use rigorous respiratory hygiene—i.e., the mouth and nose should be covered
with a disposable paper tissue when coughing or sneezing. Caregivers should also wear
a tightly fitted medical mask that cover their mouth and nose when in the same room
is present the person affected.
Conclusions
An ESE “decalog” for endocrinologists in the COVID-19 pandemic
Adequately protect yourself and ask for COVID-19 testing if exposed.
Avoid unnecessary routine appointments in person.
Put in place online/email/phone consultation services.
Closely monitor glycemic control in patients with diabetes.
Recommend to persons with diabetes a strict adherence to general preventive measures.
Counsel persons with diabetes about specific measures related to their disease management
(sick day rules) in case of infection by COVID-19.
Counsel persons with diabetes particularly if aged over 65 and obese about referrals
for management in case of suspected infection by COVID-19.
Avoid undernourishment with dietary or adjunctive measures if clinically indicated.
Closely monitor clinical conditions of patients with adrenal insufficiency.
Adapt increased replacement treatment if clinically indicated in patients with adrenal
insufficiency.