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      Dopamine Receptors: From Structure to Function

      , , , ,

      Physiological Reviews

      American Physiological Society

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          Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

          A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.
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            Multiple receptors for dopamine.

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              D1 dopamine receptors in prefrontal cortex: involvement in working memory.

               P Rakic,  T Sawaguchi (1991)
              The prefrontal cortex is involved in the cognitive process of working memory. Local injections of SCH23390 and SCH39166, selective antagonists of the D1 dopamine receptor, into the prefrontal cortex of rhesus monkeys induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades. The deficit was dose-dependent and sensitive to the duration of the delay period. These D1 antagonists had no effect on performance in a control task requiring visually guided saccades, indicating that sensory and motor functions were unaltered. Thus, D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex.
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                Author and article information

                Journal
                Physiological Reviews
                Physiological Reviews
                American Physiological Society
                0031-9333
                1522-1210
                January 1998
                January 1998
                : 78
                : 1
                : 189-225
                Article
                10.1152/physrev.1998.78.1.189
                © 1998

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