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      Renin-angiotensin system and atherothrombotic disease: from genes to treatment.

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      Journal: Archives of internal medicine
      Keywords: Angiotensin II, genetics, physiology, Angiotensin-Converting Enzyme Inhibitors, pharmacology, therapeutic use, Animals, Arteriosclerosis, drug therapy, etiology, Clinical Trials as Topic, Endothelium, Vascular, drug effects, Growth Substances, Humans, Inflammation, Lipoproteins, LDL, Oxidative Stress, Renin-Angiotensin System, Risk Factors, Signal Transduction

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          Abstract

          The renin-angiotensin system plays a central role in the pathogenesis of cardiovascular disease. At the molecular and cellular levels, angiotensin II, the main effector peptide of the system, stimulates key components of atherosclerosis. Trials in animals and humans indicate that blocking renin-angiotensin system pathways decreases atherosclerotic plaque progression and ischemic events. This review provides a broad overview of the entire role of the renin-angiotensin system in atherothrombotic disease, ranging from molecular pathways to human genetics to the latest clinical trials.

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          PubMed ID:: 12767951
          DOI:: 10.1001/archinte.163.10.1155

          ScienceOpen disciplines: Chemistry
          Keywords: Angiotensin II,genetics,physiology,Angiotensin-Converting Enzyme Inhibitors,pharmacology,therapeutic use,Animals,Arteriosclerosis,drug therapy,etiology,Clinical Trials as Topic,Endothelium, Vascular,drug effects,Growth Substances,Humans,Inflammation,Lipoproteins, LDL,Oxidative Stress,Renin-Angiotensin System,Risk Factors,Signal Transduction
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          ScienceOpen disciplines: Chemistry
          Keywords: Angiotensin II, genetics, physiology, Angiotensin-Converting Enzyme Inhibitors, pharmacology, therapeutic use, Animals, Arteriosclerosis, drug therapy, etiology, Clinical Trials as Topic, Endothelium, Vascular, drug effects, Growth Substances, Humans, Inflammation, Lipoproteins, LDL, Oxidative Stress, Renin-Angiotensin System, Risk Factors, Signal Transduction

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