7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      In vivo functional implications of isoproterenol-mediated relaxation of isolated human iris sphincter.

      1 ,
      Journal of ocular pharmacology

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The isolated human iris sphincter contracted with carbachol produced relaxation with an average ED50 of 1.30 x 10(-7) M for (-)-isoproterenol. The effect is sensitive to block by (-)-timolol with KB 3 x 10(-9) M. The magnitude of the average relaxation mediated by the beta-adrenoceptor agonist was only 31%. Lowering of the temperature did not potentiate the effect of (-)-isoproterenol to a significant extent. Thus, in contrast to bovine iris sphincter, where the beta-adrenoceptor mediated response of (-)-isoproterenol produces a maximum relaxation or complete mydriasis, the maximum beta-adrenoceptor mediated mydriasis of human iris may not be more than 1/3 of the maximum pupillary dilatation achieved by physiologic or pharmacologic procedures.

          Related collections

          Author and article information

          Journal
          J Ocul Pharmacol
          Journal of ocular pharmacology
          8756-3320
          8756-3320
          1991
          : 7
          : 4
          Affiliations
          [1 ] College of Pharmacy, Ohio State University, Columbus.
          Article
          1809789
          409eccb5-e268-457a-8625-4d8c2deb551e
          History

          Comments

          Comment on this article