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Immunosenescence and infectious diseases.

Microbes and Infection / Institut Pasteur

Aging, immunology, Animals, Communicable Diseases, Humans, Immune System, Vaccines

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      Abstract

      Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vaccines. Impairments of cellular, humoral and innate immunity in the elderly, contributing to increased incidence of infectious diseases, are discussed in this review.

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      Journal
      11580980

      Chemistry

      Aging, immunology, Animals, Communicable Diseases, Humans, Immune System, Vaccines

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