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      Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation.

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          Abstract

          Vascular calcification is a common health problem related to oxidative stress, inflammation, and circulating calciprotein particles (CPP). Hydrogen sulfide is an endogenous signaling molecule with antioxidant properties and potential for drug development targeting redox signaling. Yet, its molecular mechanisms of action in vascular smooth muscle cell (VSMC) calcification have not been delineated. We therefore sought to identify key pathways involved in the calcification-inhibitory properties of sulfide employing our recently developed CPP-induced VSMC calcification model.

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          Author and article information

          Journal
          Atherosclerosis
          Atherosclerosis
          Elsevier BV
          1879-1484
          0021-9150
          Oct 2017
          : 265
          Affiliations
          [1 ] Department of Clinical Research, University of Bern, Switzerland; The National Centre of Competence in Research (NCCR) "Kidney.CH - Kidney Control of Homeostasis", Switzerland.
          [2 ] Department of Clinical Research, University of Bern, Switzerland.
          [3 ] Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands.
          [4 ] Department of Nephrology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
          [5 ] Division of Molecular & Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; The National Centre of Competence in Research (NCCR) "Kidney.CH - Kidney Control of Homeostasis", Switzerland.
          [6 ] Clinical and Experimental Sciences, Faculty of Medicine, Southampton General Hospital, Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.
          [7 ] Department of Clinical Research, University of Bern, Switzerland; The National Centre of Competence in Research (NCCR) "Kidney.CH - Kidney Control of Homeostasis", Switzerland. Electronic address: andreas.pasch@dkf.unibe.ch.
          Article
          S0021-9150(17)31234-0
          10.1016/j.atherosclerosis.2017.08.012
          28865326
          40b6e19b-ac19-4349-bf44-f88681f76574
          History

          Calciprotein particles,Vascular smooth muscle cells,NQO1,Sulfide,H(2)S/HS(−)

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