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      High-volume online haemodiafiltration improves erythropoiesis-stimulating agent (ESA) resistance in comparison with low-flux bicarbonate dialysis: results of the REDERT study

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          Abstract

          In haemodialysis (HD) patients, anaemia is associated with reduced survival. Despite treatment with erythropoiesis-stimulating agents (ESAs), a large number of patients with chronic kidney disease show resistance to this therapy and require much higher than usual doses of ESAs in order to maintain the recommended haemoglobin (Hb) target, and recent studies suggest that hepcidin (HEP) may mediate the ESA resistance index (ERI). High-volume online haemodiafiltration (HV-OL-HDF) has been shown to improve anaemia and to reduce the need for ESAs in HD patients; this effect is associated with a reduced inflammatory state in these patients. The aim of the REDERT study (role of haemodiafiltration on ERI) was to investigate the effect of different dialysis techniques on ERI and HEP levels in chronic dialysis patients.

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          Author and article information

          Journal
          Nephrology Dialysis Transplantation
          Nephrology Dialysis Transplantation
          Oxford University Press (OUP)
          0931-0509
          1460-2385
          March 23 2015
          April 01 2015
          November 10 2014
          April 01 2015
          : 30
          : 4
          : 682-689
          Article
          10.1093/ndt/gfu345
          25385719
          40bfdff1-412a-4869-8d6a-8ba05e57ecb8
          © 2015
          History

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