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Abstract
In this work, the chemiluminescence method was engaged for the first time to detect
the active oxygen species during sonodynamic action in vitro and in vivo. We used
FCLA (3,7-dihydro-6-[4-[2-[N'-(5-fluoresceinyl)thioureido]-ethoxy]phenyl]-2-methylimidazo[1,2-a]pyrazin-3-one
sodium salt), which can selectively react with singlet oxygen ((1)O(2)) or superoxide
anion (O(2)(-)) to emit photons, to detect in real time oxygen free radical formation
in the sonosensitization of hematoporphyrin derivative. The results show that (1)O(2)
is involved in the sonosensitization. In in vivo experiments, a tumor-imaging method
by sonodynamic chemiluminescence detection was established. This method could have
potential applications in clinics for tumor diagnosis.