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      FCLA chemiluminescence from sonodynamic action in vitro and in vivo

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      Cancer Letters
      Elsevier BV

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          Abstract

          In this work, the chemiluminescence method was engaged for the first time to detect the active oxygen species during sonodynamic action in vitro and in vivo. We used FCLA (3,7-dihydro-6-[4-[2-[N'-(5-fluoresceinyl)thioureido]-ethoxy]phenyl]-2-methylimidazo[1,2-a]pyrazin-3-one sodium salt), which can selectively react with singlet oxygen ((1)O(2)) or superoxide anion (O(2)(-)) to emit photons, to detect in real time oxygen free radical formation in the sonosensitization of hematoporphyrin derivative. The results show that (1)O(2) is involved in the sonosensitization. In in vivo experiments, a tumor-imaging method by sonodynamic chemiluminescence detection was established. This method could have potential applications in clinics for tumor diagnosis.

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          Author and article information

          Journal
          Cancer Letters
          Cancer Letters
          Elsevier BV
          03043835
          August 2002
          August 2002
          : 182
          : 2
          : 141-145
          Article
          10.1016/S0304-3835(02)00070-8
          12048159
          40c5af62-91e3-4bc1-80d8-7e5811f06cde
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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