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      Transposable elements and the epigenetic regulation of the genome.

      1 ,
      Nature reviews. Genetics
      Springer Science and Business Media LLC

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          Abstract

          Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the expression and mobility of transposable elements (TEs). Owing to their ability to recruit the silencing machinery, TEs have served as building blocks for epigenetic phenomena, both at the level of single genes and across larger chromosomal regions. Important progress has been made recently in understanding these silencing mechanisms. In addition, new insights have been gained into how this silencing has been co-opted to serve essential functions in 'host' cells, highlighting the importance of TEs in the epigenetic regulation of the genome.

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          Author and article information

          Journal
          Nat Rev Genet
          Nature reviews. Genetics
          Springer Science and Business Media LLC
          1471-0056
          1471-0056
          Apr 2007
          : 8
          : 4
          Affiliations
          [1 ] Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
          Article
          nrg2072
          10.1038/nrg2072
          17363976
          40cc363e-0988-43c3-ad99-ec8c0b7510a2
          History

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