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Salutary effect of adjunctive intracoronary nicorandil administration on restoration of myocardial blood flow and functional improvement in patients with acute myocardial infarction
Yasuhiko Sakata ,
Kazuhisa Kodama ,
Kazuo Komamura ,
Young-Jae Lim ,
Fuminobu Ishikura ,
Atsushi Hirayama ,
Masafumi Kitakaze ,
Tohru Masuyama ,
Masatsugu Hori
June 1997
June 1997
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Abstract
Salutary effect of nicorandil, a K+ adenosine triphosphate channel opener, on restoration
of myocardial blood flow and functional improvement after coronary revascularization
was investigated in 20 patients with first anterior acute myocardial infarction. Ten
patients received intracoronary administration of nicorandil (2 mg) after coronary
revascularization; the other 10 patients received coronary revascularization only
and served as control subjects. Myocardial contrast echocardiography and two-dimensional
echocardiography were performed to assess microvascular integrity and regional function
in the infarcted area. Nicorandil improved peak contrast intensity ratio (p < 0.001),
calculated as the ratio of peak contrast intensity in the infarcted and noninfarcted
areas, indicating the restoration of myocardial blood flow to the infarcted myocardium.
Regional wall motion improved more significantly in 1 month in patients who received
nicorandil (p < 0.01). Thus our results suggested the usefulness of intracoronary
nicorandil administration after coronary revascularization for restoring blood flow
and functional improvement in patients with acute myocardial infarction.