Contact lens is an optical device that is commonly used to correct refractive errors of the eye. Improper care may lead to ocular related complications. This was a descriptive study to assess contact lens care practice and knowledge on contact lens use among medical students of Universiti Teknologi MARA (UiTM). Out of seven proper practices of contact lens care listed, only hand washing practice was adhered by most of the wearer. Both groups of contact lens wearer and non-wearers showed a moderate level of knowledge with regards to lens care. Educational programs on awareness and safety usage of contact lens should be emphasized particularly to the medical students