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      Endothelial stem cells and precursors for tissue engineering: cell source, differentiation, selection, and application.

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      Tissue engineering. Part B, Reviews

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          Abstract

          Endothelial cells are of great interest because of their potential in cell therapy for vascular diseases and ischemic tissue, tissue engineering for vascular grafts and vascularized tissue beds, and modeling for pharmaceutical transport across endothelial barriers. However, limited availability and proliferation capability of mature endothelial cells hampers development of these applications. Recent advances in stem cell technology have enabled researchers to derive endothelial or endothelial-like cells from stem cells or other precursor populations. The current state of these cell sources and their in vitro differentiation, selection, and applications are discussed in this review.

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          Author and article information

          Journal
          Tissue Eng Part B Rev
          Tissue engineering. Part B, Reviews
          1937-3368
          1937-3368
          Mar 2008
          : 14
          : 1
          Affiliations
          [1 ] Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
          Article
          10.1089/teb.2007.0304
          18454639

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