For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
22
views
49
references
 Top references
cited by
22
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      69
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Sex Differences in the Reinstatement of Methamphetamine Seeking after Forced Abstinence in Sprague-Dawley Rats

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Preventing relapse to drug abuse is one of the struggles faced by clinicians in order to treat patients with substance use disorders (DSM-5). There is a large body of clinical evidence suggesting differential characteristics of the disorder in men and women, which is in line with preclinical findings as well. The aim of this study was to assess differences in relapse-like behavior in methamphetamine (METH) seeking after a period of forced abstinence, which simulates the real clinical situation very well. Findings from such study might add new insights in gender differences in relapse mechanisms to previous studies, which employ a classical drug or cue-induced reinstatement procedure following the extinction training. Adult male and female Sprague-Dawley rats were used in IV self-administration procedure conducted in operant boxes using nose-poke operandi (Coulborn Instruments, USA). Active nose-poke resulted in activation of the infusion pump to deliver one intravenous infusion of METH (0.08 mg/kg). After baseline drug intake was established (maintenance phase), a period of forced abstinence was initiated and rats were kept singly in their home cages for 14 days. Finally, one reinstatement session in operant boxes was conducted. Females were found to self-administer significantly lower dose of METH. The relapse rate was assessed as a number of active nose-pokes during the reinstatement session, expressed as a percentage of active nose-poking during the maintenance phase. Females displayed approximately 300% of active nose-pokes compared to 50% in males. This indicates higher vulnerability to relapse of METH seeking behavior in female rats. This effect was detected in all females, independently of current phase of their estrous cycle. Therefore, this paradigm using operant drug self-administration and reinstatement of drug-seeking after forced abstinence model can be used for preclinical screening for potential new anti-relapse medications specific for women.

          Related collections

          Most cited references49

          • Record: found
          • Abstract: found
          • Article: not found

          Sex differences in the neurobiology of drug addiction.

          Samara Bobzean, Aliza K DeNobrega, Linda Perrotti (2014)
          Epidemiological data demonstrate that while women report lower rates of drug use than men, the number of current drug users and abusers who are women continues to increase. In addition women progress through the phases of addiction differently than men; women transition from casual drug use to addiction faster, are more reactive to stimuli that trigger relapse, and have higher rates of relapse then men. Sex differences in physiological and psychological responses to drugs of abuse are well documented and it is well established that estrogen effects on dopamine (DA) systems are largely responsible for these sex differences. However, the downstream mechanisms that result from interactions between estrogen and the effects of drugs of abuse on the DA system are just beginning to be explored. Here we review the basic neurocircuitry which underlies reward and addiction; highlighting the neuroadaptive changes that occur in the mesolimbic dopamine reward and anti-reward/stress pathways. We propose that sex differences in addiction are due to sex differences in the neural systems which mediate positive and negative reinforcement and that these differences are modulated by ovarian hormones. This forms a neurobehavioral basis for the search for the molecular and cellular underpinnings that uniquely guide motivational behaviors and make women more vulnerable to developing and sustaining addiction than men. Copyright © 2014 Elsevier Inc. All rights reserved.
          Article 0 comments Cited 75 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Sex differences in striatal dopamine release in healthy adults.

            Cynthia Munro, Mary E McCaul, Dean F Wong … (2006)
            Sex differences in addictive disorders have been described. Preclinical studies have implicated the striatal dopamine system in these differences, but human studies have yet to substantiate these findings. Using positron emission tomography (PET) scans with high-specific-activity [11C] raclopride and a reference tissue approach, we compared baseline striatal dopamine binding potential (BP) and dopamine release in men and women following amphetamine and placebo challenges. Subjective drug effects and plasma cortisol and growth hormone responses were also examined. Although there was no sex difference in baseline BP, men had markedly greater dopamine release than women in the ventral striatum. Secondary analyses indicated that men also had greater dopamine release in three of four additional striatal regions. Paralleling the PET findings, men's ratings of the positive effects of amphetamine were greater than women's. We found no sex difference in neuroendocrine hormone responses. We report for the first time a sex difference in dopamine release in humans. The robust dopamine release in men could account for increased vulnerability to stimulant use disorders and methamphetamine toxicity. Our findings indicate that future studies should control for sex and may have implications for the interpretation of sex differences in other illnesses involving the striatum.
            Article 0 comments Cited 75 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Time to relapse following treatment for methamphetamine use: a long-term perspective on patterns and predictors.

              Mary-Lynn Brecht, Diane Herbeck (2014)
              This paper describes methamphetamine (MA) use patterns, specifically the duration of continuing abstinence ("time to relapse") for periods averaging 5 years post-discharge from treatment for MA use, and the relationship with selected user and treatment characteristics. A sample of 350 treatment admissions from a large county substance use disorder (SUD) treatment system was randomly selected (within gender, race/ethnicity, treatment modality strata). Retrospective self-report data are from natural history interviews (NHI) conducted approximately 3 years after treatment and a follow-up of 2-3 years later. Relapse is defined as any use of MA with time as the number of months of continuous MA abstinence after treatment discharge until relapse. This outcome was constructed from a monthly MA use timeline using NHI data. A Cox model was used to examine time to relapse and predictors. Sixty-one percent of the sample relapsed to MA use within 1 year after treatment discharge and 14% during years 2-5. Significant protective factors predicting longer time to relapse included having experienced serious MA-related psychiatric/behavioral problems (hazard ratio [HR]=0.75, p=0.027), longer duration of the index treatment episode (HR=0.93, p=0.001), and participating in self-help or other treatment during the post-treatment abstinence period (HR=0.29, p<0.001); risk factors for shorter time to relapse included having a parent with alcohol and/or drug use problems (HR=1.35, p=0.020) and involvement in MA sales (HR=1.48, p=0.002). Results contribute a long-term perspective on patterns of MA use following treatment and support a need for early post-treatment and long-term continuing care and relapse-prevention services. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
              Article 0 comments Cited 75 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Jana Ruda-Kucerova: URI : http://frontiersin.org/people/u/114434
                Vincenzo Micale: URI : http://frontiersin.org/people/u/34018
                Alexandra Sulcova: URI : http://frontiersin.org/people/u/108572
                Journal
                Journal ID (nlm-ta): Front Psychiatry
                Journal ID (iso-abbrev): Front Psychiatry
                Journal ID (publisher-id): Front. Psychiatry
                Title: Frontiers in Psychiatry
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 1664-0640
                Publication date (Electronic): 06 July 2015
                Publication date Collection: 2015
                Volume: 6
                Electronic Location Identifier: 91
                Affiliations
                [1] 1Experimental and Applied Neuropsychopharmacology Group, Central European Institute of Technology (CEITEC), Masaryk University , Brno, Czech Republic
                [2] 2Department of Pharmacology, Faculty of Medicine, Masaryk University , Brno, Czech Republic
                [3] 3Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University , Brno, Czech Republic
                [4] 4Section of Pharmacology, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania , Catania, Italy
                Author notes

                Edited by: Miriam Melis, University of Cagliari, Italy

                Reviewed by: Angelo Giovanni Icro Maremmani, University of Pisa, Italy; Cristina Cadoni, National Research Council, Italy

                *Correspondence: Jana Ruda-Kucerova, CEITEC – Central European Institute of Technology, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic, jkucer@ 123456med.muni.cz

                Specialty section: This article was submitted to Addictive Disorders and Behavioral Dyscontrol, a section of the journal Frontiers in Psychiatry

                Article
                DOI: 10.3389/fpsyt.2015.00091
                PMC ID: 4492081
                PubMed ID: 26217239
                SO-VID: 41571f5c-2d24-46f9-89bf-85e869bf5154
                Copyright © Copyright © 2015 Ruda-Kucerova, Amchova, Babinska, Dusek, Micale and Sulcova.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 03 April 2015
                Date accepted : 09 June 2015
                Page count
                Figures: 5, Tables: 0, Equations: 0, References: 54, Pages: 8, Words: 5899
                Funding
                Funded by: “CEITEC – Central European Institute of Technology”
                Award ID: CZ.1.05/1.1.00/02.0068
                Funded by: European Regional Development
                Funded by: Masaryk University
                Award ID: MUNI/A/1116/2014
                Funded by: Masaryk University
                Award ID: MUNI/11/InGA09/2012
                Categories
                Subject: Psychiatry
                Subject: Original Research

                ScienceOpen disciplines: Clinical Psychology & Psychiatry
                Keywords: methamphetamine,reinstatement of drug-seeking behavior,forced abstinence,sex/gender differences,sprague-dawley rats
                Data availability:
                ScienceOpen disciplines: Clinical Psychology & Psychiatry
                Keywords: methamphetamine, reinstatement of drug-seeking behavior, forced abstinence, sex/gender differences, sprague-dawley rats

                Comments

                Comment on this article

                scite_

                Similar content69

                See all similar

                Cited by22

                See all cited by

                Most referenced authors234

                See all reference authors