Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET.

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Abstract

Metabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [(11)C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [(11)C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals.

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Journal

Journal ID (iso-abbrev): Eur. J. Nucl. Med. Mol. Imaging

Title: European journal of nuclear medicine and molecular imaging

Publisher: Springer Nature

ISSN (Electronic): 1619-7089

ISSN (Print): 1619-7070

Publication date (Electronic): Jan 2016

Volume: 43

Issue: 1

Affiliations

[1 ] Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Room 786, Montreal, Quebec, H3A 2B4, Canada. jonathan.dubois@mail.mcgill.ca.

[2 ] The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA.

[3 ] Translational Neuroimaging Laboratory, McGill Center for Studies in Aging, Douglas Mental Health University Institute, McGill University, Montreal, Canada.

[4 ] Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Room 786, Montreal, Quebec, H3A 2B4, Canada.

[5 ] PET Unit, McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada.

[6 ] Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, UK.

[7 ] Department of Epidemiology, Biostatistics and Occupational health, McGill University, Montreal, Canada.

[8 ] Department of Psychiatry, Douglas Mental Health University Institute / Douglas Institut Universitaire en Santé Mentale, Montreal, Canada.

[9 ] Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Room 786, Montreal, Quebec, H3A 2B4, Canada. eliane.kobayashi@mcgill.ca.

Article

Publisher Item ID: 10.1007/s00259-015-3167-6

DOI: 10.1007/s00259-015-3167-6

PubMed ID: 26290423

SO-VID: 41599c34-3715-428d-877a-2985179adcfa

History

Keywords: Healthy controls,Metabotropic glutamate receptor 5,Positron emission tomography,[11C]ABP688

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Keywords: Healthy controls, Metabotropic glutamate receptor 5, Positron emission tomography, [11C]ABP688

Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET.

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