15
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Autoradiographic Analyses of the Effects of Restraint-Induced Stress on 5-HT 1A, 5-HT 1C and 5-HT 2 Receptors in the Dorsal Hippocampus of Male and Female Rats

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Quantitative autoradiography was used to evaluate the effects of sex and either 1 or 5 daily 2-hour sessions of restraint stress on binding at 5-HT<sub>1</sub>A, 5-HT<sub>1</sub>C and 5-HT<sub>2</sub> receptors in the rat dorsal hippocampus. Neither sex nor restraint stress were found to have effects on binding at 5-HT<sub>1c</sub> or 5-HT<sub>2</sub> receptors. However, restraint stress increased binding of [<sup>3</sup>H]8-hydroxy-2-(di-n-propylamino)tetralin at 5-HT<sub>1A</sub> receptors in the CA4 region and in the infrapyramidal dentate gyrus. In addition, levels of binding at 5-HT<sub>1A</sub> receptors in the oriens and lacunosum moleculare layers of the CA1 region were significantly higher in female rats. Neither estradiol benzoate nor estradiol benzoate plus progesterone had effects on binding at hippocampal 5-HTIA receptors in ovariectomized rats, making it unlikely that the sex differences were related to stages of the estrous cycle. Stress-induced levels of corticosterone (CORT) were higher in females. Although CORT levels in blood obtained during restraint decreased from session 1 to session 5 in both male and female rats, the decrease became significant in females only. Female rats also displayed higher levels of activity in the open field. Although activity in the open field was reduced in male and female rats after restraint, these decreases were not significant. Results are discussed in relation to anxiety and depression.

          Related collections

          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1991
          1991
          07 April 2008
          : 54
          : 5
          : 454-461
          Affiliations
          Laboratory of Neuroendocrinology, The Rockefeller University, New York, N.Y., USA
          Article
          125951 Neuroendocrinology 1991;54:454–461
          10.1159/000125951
          1749460
          4161d1ed-e8d9-422c-ac03-6a4e8126e75a
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 22 October 1990
          : 01 March 1991
          Page count
          Pages: 8
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          5-HT1c receptor,Corticosterone,Stress,Sex difference,5-HT2 receptor,Serotonin,Hippocampus,Rat,5-HTA receptor

          Comments

          Comment on this article