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      Schedule-dependent inhibition of T-cell lymphoma cells by cotreatment with the mTOR inhibitor everolimus and anticancer drugs.

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          Abstract

          Everolimus (RAD001) is a novel mammalian target of rapamycin (mTOR) inhibitor, and anti-proliferative activity in various malignancies has been reported. This study evaluated the anti-tumor effects and schedule-dependent synergism of everolimus in combination with other chemotherapeutic agents in T-cell lymphoma cell lines.

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          Author and article information

          Journal
          Invest New Drugs
          Investigational new drugs
          Springer Nature
          1573-0646
          0167-6997
          Feb 2012
          : 30
          : 1
          Affiliations
          [1 ] Department of Medical Oncology, Cancer Center, Sun Yat-sen University, 651, Dongfeng Road East, Guangzhou, Guangdong 510060, People's Republic of China.
          Article
          10.1007/s10637-010-9558-4
          20960030
          416c08c1-25f4-41d5-bd8e-95723352d5e5
          History

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