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      Gonadal Function in Trisomy 21

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      Hormone Research in Paediatrics

      S. Karger AG

      Down’s syndrome, Gonadal function

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          Endocrinologic evaluation of 39 patients with trisomy 21 and associated hypogonadism demonstrated elevations of follicle-stimulating hormone and luteinizing hormone; consequently, it can be concluded that both germinal and Leydig cell function are affected. A negative correlation between testicular size and plasma follicle-stimulating hormone was documented. Plasma testosterone levels were found to be normal in male patients as were estradiol levels in female patients with trisomy 21. On the basis of these findings, the simplest and most practical diagnostic approach to evaluate germinal cell function appears to be a single plasma follicle-stimulating hormone determination supplemented by an accurate measurement of testicular volume in males.

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          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 12
          : 6
          : 345-350
          New York Medical College, New York, N.Y.; University of Texas Health Science Center at Dallas, Dallas, Tex.; Medical Genetics Unit Westchester County Medical Center, Valhalla, N.Y., and Genetics Laboratory, Letchworth Village Developmental Center, Thiells, N.Y.
          179141 Horm Res 1980;12:345–350
          © 1980 S. Karger AG, Basel

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          Pages: 6
          Short Communication


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