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      Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators.

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          Abstract

          Herniated intervertebral disc tissue has been shown to produce a number of proinflammatory mediators and cytokines, but there have been no similar studies using discs from patients with discogenic low back pain. We have compared the levels of production of interleukin-6 (IL-6), interleukin-8 (IL-8) and prostaglandin E2 (PGE2) in disc tissue from patients undergoing discectomy for sciatica (63) with that from patients undergoing fusion for discogenic low back pain (20) using an enzyme-linked immunoabsorbent assay. There was a statistically significant difference between levels of production of IL-6 and IL-8 in the sciatica and low back pain groups (p < 0.006 and p < 0.003, respectively). The high levels of proinflammatory mediator found in disc tissue from patients undergoing fusion suggest that production of proinflammatory mediators within the nucleus pulposus may be a major factor in the genesis of a painful lumbar disc.

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          Author and article information

          Journal
          J Bone Joint Surg Br
          The Journal of bone and joint surgery. British volume
          0301-620X
          0301-620X
          Mar 2002
          : 84
          : 2
          Affiliations
          [1 ] University College Dublin, the Mater Misericordiae Hospital, Ireland.
          Article
          10.1302/0301-620x.84b2.12511
          11924650
          41725069-0b6d-4967-8fcc-c2cdb0fb5919
          History

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