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      Changes in Renal Function Induced by ACE-lnhibition in the Conscious Two-Kidney, One-Clip Goldblatt Hypertensive Dog

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          Abstract

          In order to study why the diagnostic sensitivity of <sup>123</sup>I-hippurate renography for a renal artery stenosis is improved by angiotensin converting enzyme (ACE-) inhibition we used the model of the conscious chronically instrumented two-kidney, one-clip Goldblatt hypertensive dog. Urine flow (UV), renal blood flow (RBF), glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured (with constant infusion of <sup>125</sup>I-iothalamate and <sup>131</sup>I-hippurate, respectively) for both kidneys separately before and after a bolus injection of a mild unilateral renal artery stenosis (approximately 30% reduction of RBF). During ACE-inhibition, there were remarkable falls in poststenotic GFR (from 37 ± 5 to 4 ± 2 ml/min, p < 0.05), ERPF (from Ill ± 13 to 21 ± 10 ml/min, p < 0.05) and UV (from 0.86 ± 0.15 to 0.075 ± 0.045 ml/min, p < 0.05), whereas RBF of the poststenotic kidney slightly increased (from 193 ± 18 to 237 ± 27 ml/min, p < 0.05). The concentration of hippurate and thalamate in the blood remained remarkably constant while the excretion of the tracers by the poststenotic kidney diminished and renal retention of <sup>123</sup>I-hippurate was seen on the renogram. In 2 dogs, the experiments were repeated during mannitol infusion. In that situation, there was a much smaller decrease of poststenotic UV and GFR whereas ERPF even showed a small increase comparable to the RBF changes. These results suggest that the dramatic decreases in thalamate and hippurate excretion of the poststenotic kidney after acute ACE-inhibition are not due to a similarly dramatic fall in GFR or ERPF but mainly to tubular retention of the tracers.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1992
          1992
          11 December 2008
          : 60
          : 2
          : 226-231
          Affiliations
          University Hospital, Departments of Nephrology and Nuclear Medicine, Groningen, The Netherlands
          Article
          186744 Nephron 1992;60:226–231
          10.1159/000186744
          1553009
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          ACE inhibition, Hippurate, Renovascular hypertension, Renography

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