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Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity.
Qinghua Sun
1 ,
Peibin Yue ,
Jeffrey A Deiuliis ,
Carey N Lumeng ,
Thomas Kampfrath ,
Michael B Mikolaj ,
Ying Cai ,
Michael C Ostrowski ,
Bo Lu ,
Sampath Parthasarathy ,
Robert D Brook ,
Susan D Moffatt-Bruce ,
Lung Chi Chen ,
Sanjay Rajagopalan
Feb 03 2009
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Abstract
There is a strong link between urbanization and type 2 diabetes mellitus. Although a multitude of mechanisms have been proposed, there are no studies evaluating the impact of ambient air pollutants and the propensity to develop type 2 diabetes mellitus. We hypothesized that exposure to ambient fine particulate matter (<2.5 mum; PM(2.5)) exaggerates diet-induced insulin resistance, adipose inflammation, and visceral adiposity.