ERK1/2/p53 and NF-κB dependent-PUMA activation involves in doxorubicin-induced cardiomyocyte apoptosis.

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Abstract

Numerous studies have demonstrated that Doxorubicin (DOX) induces cardiomyocyte apoptosis, which is associated with DOX-induced acute and chronic cardiotoxicity. DOX activated ERP1/2 and NF-KB signals has been linked to DOX-induced apoptosis and cardiotoxicity. However, the underlying mechanisms responsible for DOX-induced apoptosis have not been completely elucidated. In this study, we determine whether both ERK1/2/p53-dependent and NF-κB dependent-PUMA activation was related to DOX-induced apoptosis in H9c2 cells.

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Journal

Journal ID (iso-abbrev): Eur Rev Med Pharmacol Sci

Title: European review for medical and pharmacological sciences

ISSN (Electronic): 2284-0729

ISSN (Print): 1128-3602

Publication date (Electronic): June 2016

Volume: 20

Issue: 11

Affiliations

[1 ] Department of Cardiovascular Medicine, Yuhuangding Hospital of Yantai, Yantai, Shandong, China.ddbrzyy@126.com.

Article

PubMed ID: 27338072

SO-VID: 41a92b5f-17a3-40cc-b377-28892b566ba6

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