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      Amino-Aciduria and Enzymuria in Patients with Artificial Heart Valves

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          Abstract

          Fifteen patients with artificial heart valves and evidence of chronic intravascular haemolysis were studied for proximal tubular dysfunction. Three patients had haemosiderinuria and haemoglobinuria; 2 had haemoglobinuria alone. Increased urinary amino acid nitrogen occurred in 8, raised fractional β<sub>2</sub>-microglobulin excretion in 2, hypophosphataemia in 4, renal glycosuria in 1 and enhanced fractional urate excretion in 1. Urinary N-acetyl-β-glucosaminidase (NAG) excretion increased in 7; the mean urinary NAG/creatinine ratio was raised to twice the upper limit of the normal range. Renal haemosiderosis due to chronic intravascular haemolysis could cause tubular injury.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1992
          1992
          12 December 2008
          : 62
          : 1
          : 18-21
          Affiliations
          aDepartment of Medicine, University of Hong Kong, Queen Mary Hospital and Grantham Hospital, and bDepartment of Clinical Biochemistry, Queen Mary Hospital, Hong Kong
          Article
          186988 Nephron 1992;62:18–21
          10.1159/000186988
          1436285
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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