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      Bacteriophages can treat and prevent Pseudomonas aeruginosa lung infections.

      The Journal of Infectious Diseases

      Amino Acid Sequence, Animals, Cytokines, metabolism, Inflammation, Luminescent Measurements, Lung Diseases, microbiology, prevention & control, Male, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Pseudomonas Infections, Pseudomonas Phages, chemistry, genetics, physiology, Pseudomonas aeruginosa, virology, Survival Analysis, Whole Body Imaging

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          Abstract

          Antibiotic-resistant bacteria threaten life worldwide. Although new antibiotics are scarce, the use of bacteriophages, viruses that infect bacteria, is rarely proposed as a means of offsetting this shortage. Doubt also remains widespread about the efficacy of phage therapy despite recent encouraging results. Using a bioluminescent Pseudomonas aeruginosa strain, we monitored and quantified the efficacy of a bacteriophage treatment in mice during acute lung infection. Bacteriophage treatment not only was effective in saving animals from lethal infection, but also was able to prevent lung infection when given 24 h before bacterial infection, thereby extending the potential use of bacteriophages as therapeutic agents to combat bacterial lung infection.

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          Journal
          20196657
          10.1086/651135

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