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      Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.

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          Abstract

          Within the vertebrate nervous system, the presence of many different lineages of neurons and glia complicates the molecular characterization of single neuronal populations. In order to elucidate molecular mechanisms underlying the specification and development of corticospinal motor neurons (CSMN), we purified CSMN at distinct stages of development in vivo and compared their gene expression to two other pure populations of cortical projection neurons: callosal projection neurons and corticotectal projection neurons. We found genes that are potentially instructive for CSMN development, as well as genes that are excluded from CSMN and are restricted to other populations of neurons, even within the same cortical layer. Loss-of-function experiments in null mutant mice for Ctip2 (also known as Bcl11b), one of the newly characterized genes, demonstrate that it plays a critical role in the development of CSMN axonal projections to the spinal cord in vivo, confirming that we identified central genetic determinants of the CSMN population.

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          0896-6273
          0896-6273
          Jan 20 2005
          : 45
          : 2
          Affiliations
          [1 ] MGH-HMS Center for Nervous System Repair, Departments of Neurosurgery and Neurology, Program in Neuroscience and Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
          Article
          S0896627304008530
          10.1016/j.neuron.2004.12.036
          15664173
          41db3757-56b5-4eaf-9948-2ea7701a51b9
          History

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