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Abstract
The ability to achieve and maintain penile erection is necessary for successful copulation.
Studies have demonstrated that dopamine receptor stimulation in the paraventricular
nucleus (PVN) of the hypothalamus induces penile erection in rodents, and the dopamine
agonist apomorphine has been used to treat erectile dysfunction. The aim of this study
was to determine the electrophysiological characteristics of PVN neuronal firing activity
in anaesthetised rodents during apomorphine-induced erection. Our findings can be
placed in two categories; those effects that occur immediately upon apomorphine administration
and continue for up to several minutes prior to penile erection, deemed 'pre-erectile',
and those effects that were only observed during penile erection and seminal emission.
In the pre-erectile period, apomorphine acts on two different populations of PVN neurons
to increase or decrease firing rates and increases alpha1 frequency band power in
local field potentials. Decreased delta and increased theta frequency power in PVN
local field potentials occur only during penile erection and seminal emission. These
studies provide further understanding of the coordinated neuronal activity that occurs
in the PVN during apomorphine-induced penile erection.