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      Heart failure with anemia: novel findings on the roles of renal disease, interleukins, and specific left ventricular remodeling processes.

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          Abstract

          Anemia is a highly prevalent and strong independent prognostic marker in heart failure (HF), yet this association is not completely understood. Whether anemia is simply a marker of disease severity and concomitant chronic kidney disease or represents the activation of other detrimental pathways remains uncertain. We sought to determine which pathophysiological pathways are exacerbated in patients with HF, reduced ejection fraction (HFrEF) and anemia in comparison with those without anemia.

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          Author and article information

          Journal
          Circ Heart Fail
          Circulation. Heart failure
          Ovid Technologies (Wolters Kluwer Health)
          1941-3297
          1941-3289
          Sep 2014
          : 7
          : 5
          Affiliations
          [1 ] From the Montreal Heart Institute, Department of Medicine (E.O'M., J.L.R., M.W., K.R., A.D., J.L., N.R., M.L., J.-C.T., S.d.D.), Department of Pharmacology (P.-E.N., M.G.S.), Department of Biostatistics Montreal Heart Innovations Coordinating Center (MHICC) (L.B.), and Department of Nephrology, Hôpital du Sacré-Cœur de Montréal (F.M.), Université de Montréal, Montreal, Quebec, Canada. eileen.omeara@umontreal.ca.
          [2 ] From the Montreal Heart Institute, Department of Medicine (E.O'M., J.L.R., M.W., K.R., A.D., J.L., N.R., M.L., J.-C.T., S.d.D.), Department of Pharmacology (P.-E.N., M.G.S.), Department of Biostatistics Montreal Heart Innovations Coordinating Center (MHICC) (L.B.), and Department of Nephrology, Hôpital du Sacré-Cœur de Montréal (F.M.), Université de Montréal, Montreal, Quebec, Canada.
          Article
          CIRCHEARTFAILURE.114.001100
          10.1161/CIRCHEARTFAILURE.114.001100
          25027873
          41eac549-4fb5-40c9-9996-a3ba2ab63d93
          History

          heart failure,anemia,biomarkers,inflammation,renal insufficiency, chronic,ventricular remodeling

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