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      Low-Pressure Receptor Activity and Exaggerated Natriuresis in Essential Hypertension

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          Abstract

          Urinary sodium excretion, central hemodynamics, and mean arterial pressure (MAP) were studied in 7 normal subjects and 19 hypertensive patients during both central hypervolemia by water immersion to the neck (NI) and extracellular volume expansion by i.v. saline infusion. During 2-hour NI, 12 out of the 19 hypertensives exhibited a significant fall in MAP (p < 0.001). Exaggerated natriuresis did not occur in these patients (ns). In the remaining 7 hypertensive patients in whom, during NI, MAP was unchanged, exaggerated natriuresis was found (p < 0.001). During saline infusion, MAP was either unchanged or increased and exaggerated natriuresis was found in all hypertensive patients (p < 0.001) previously submitted to NI. Our findings suggest that a high MAP is a major determinant of exaggerated natriuresis in arterial hypertension.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 40
          : 3
          : 309-315
          Affiliations
          aIstituto di Semeiotica Medica, University of Parma, and bDivision of Cardiology, Parma, Italy
          Article
          183484 Nephron 1985;40:309–315
          10.1159/000183484
          4010845
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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