For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
32
views
17
references
 Top references
cited by
6
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      201
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      The serum level of 25-hydroxyvitamin D for maximal suppression of parathyroid hormone in children: the relationship between 25-hydroxyvitamin D and parathyroid hormone

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose

          Serum level of 25-hydroxyvitamin D (25-OHD) is considered as the most appropriate marker of vitamin D status. However, only a few studies have investigated the relationship between 25-OHD and parathyroid hormone (PTH) in children. To this end, this study was aimed at evaluating the lowest 25-OHD level that suppresses the production of parathyroid hormone in children.

          Methods

          A retrospective record review was performed for children aged 0.2 to 18 years (n=193; 106 boys and 87 girls) who underwent simultaneous measurements of serum 25-OHD and PTH levels between January 2010 and June 2014.

          Results

          The inflection point of serum 25-OHD level for maximal suppression of PTH was at 18.0 ng/mL (95% confidence interval, 14.3–21.7 ng/mL). The median PTH level of the children with 25-OHD levels of <18.0 ng/mL was higher than that of children with 25-OHD levels ≥ 18.0 ng/mL ( P<0.0001). The median calcium level of children with 25-OHD levels<18.0 ng/mL was lower than that of children with 25-OHD levels≥18.0 ng/mL ( P=0.0001). The frequency of hyperparathyroidism was higher in the children with 25-OHD levels<18.0 ng/mL than in the children with 25-OHD levels≥18.0 ng/mL ( P<0.0001). Hypocalcemia was more prevalent in the children with 25-OHD levels<18.0 ng/mL than in the children with 25-OHD levels≥18.0 ng/mL ( P<0.0001).

          Conclusion

          These data suggest that a vitamin D level of 18.0 ng/mL could be the criterion for 25-OHD deficiency in children at the inflection point of the maximal suppression of PTH.

          Related collections

          Most cited references17

          • Record: found
          • Abstract: found
          • Article: not found

          Prevalence of vitamin D deficiency among healthy adolescents.

          E. Grace, Kerrin DePeter, Stuart Gordon … (2004)
          Although vitamin D deficiency has been documented as a frequent problem in studies of young adults, elderly persons, and children in other countries, there are limited data on the prevalence of this nutritional deficiency among healthy US teenagers. To determine the prevalence of vitamin D deficiency in healthy adolescents presenting for primary care. A cross-sectional clinic-based sample. An urban hospital in Boston. Three hundred seven adolescents recruited at an annual physical examination to undergo a blood test and nutritional and activity assessments. Serum levels of 25-hydroxyvitamin D (25OHD) and parathyroid hormone, anthropometric data, nutritional intake, and weekly physical activity and lifestyle variables that were potential risk factors for hypovitaminosis D. Seventy-four patients (24.1%) were vitamin D deficient (serum 25OHD level,
          Article 0 comments Cited 163 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake.

            Leifur Franzson, Orvar Gunnarsson, Olafur S. Indridason … (2005)
            Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known. Serum 25-hydroxyvitamin D is the generally accepted indicator of vitamin D status, but no universal reference level has been reached. To investigate the relative importance of high calcium intake and serum 25-hydroxyvitamin D for calcium homeostasis, as determined by serum intact parathyroid hormone (PTH). Cross-sectional study of 2310 healthy Icelandic adults who were divided equally into 3 age groups (30-45 years, 50-65 years, or 70-85 years) and recruited from February 2001 to January 2003. They were administered a semi-quantitative food frequency questionnaire, which assessed vitamin D and calcium intake. Participants were further divided into groups according to calcium intake ( 1200 mg/d) and serum 25-hydroxyvitamin D level ( 18 ng/mL). Serum intact PTH as determined by calcium intake and vitamin D. A total of 944 healthy participants completed all parts of the study. After adjusting for relevant factors, serum PTH was lowest in the group with a serum 25-hydroxyvitamin D level of more than 18 ng/mL but highest in the group with a serum 25-hydroxyvitamin D level of less than 10 ng/mL. At the low serum 25-hydroxyvitamin D level (<10 ng/mL), calcium intake of less than 800 mg/d vs more than 1200 mg/d was significantly associated with higher serum PTH (P = .04); and at a calcium intake of more than 1200 mg/d, there was a significant difference between the lowest and highest vitamin D groups (P = .04). As long as vitamin D status is ensured, calcium intake levels of more than 800 mg/d may be unnecessary for maintaining calcium metabolism. Vitamin D supplements are necessary for adequate vitamin D status in northern climates.
            Article 0 comments Cited 106 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Functional indices of vitamin D status and ramifications of vitamin D deficiency.

              Robert Heaney (2004)
              Serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations are currently recognized as the functional status indicator for vitamin D. Evidence is reviewed that shows that serum 25(OH)D3 concentrations of < 80 nmol/L are associated with reduced calcium absorption, osteoporosis, and increased fracture risk. For typical older individuals, supplemental oral intakes of approximately 1300 IU/d are required to reach the lower end of the optimal range. Evidence of substantial problems in routine clinical measurement of serum 25(OH)D3 concentrations among patients is cited. There is great need for standardization and improved reproducibility and sensitivity of measurements of serum 25(OH)D3 concentrations.
              Article 0 comments Cited 80 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Korean J Pediatr
                Journal ID (iso-abbrev): Korean J Pediatr
                Journal ID (publisher-id): KJP
                Title: Korean Journal of Pediatrics
                Publisher: The Korean Pediatric Society
                ISSN (Print): 1738-1061
                ISSN (Electronic): 2092-7258
                Publication date (Print): February 2017
                Publication date (Electronic): 27 February 2017
                Volume: 60
                Issue: 2
                Pages: 45-49
                Affiliations
                [1 ]Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea.
                [2 ]Clinical Trial Center, Ewha Womans University Medical Center, Seoul, Korea.
                Author notes
                Corresponding author: Hae Soon Kim, MD. Department of Pediatrics, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Korea. Tel: +82-2-2650-5569, Fax: +82-2-2650-3718, hyesk@ 123456ewha.ac.kr
                Article
                DOI: 10.3345/kjp.2017.60.2.45
                PMC ID: 5346508
                PubMed ID: 28289433
                SO-VID: 41f0c0ce-4bf9-4135-8af5-4a9f89707fd3
                Copyright © Copyright © 2017 by The Korean Pediatric Society
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 16 July 2016
                Date revision received : 18 October 2016
                Date accepted : 25 October 2016
                Categories
                Subject: Original Article

                ScienceOpen disciplines: Pediatrics
                Keywords: vitamin d,vitamin d deficiency,parathyroid hormone
                Data availability:
                ScienceOpen disciplines: Pediatrics
                Keywords: vitamin d, vitamin d deficiency, parathyroid hormone

                Comments

                Comment on this article

                scite_

                Similar content201

                See all similar

                Cited by6

                See all cited by

                Most referenced authors557

                See all reference authors