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      The roles of long noncoding RNA in epigenetic regulation

      abstract
      1 , 2 , 3 ,
      Epigenetics & Chromatin
      BioMed Central
      Epigenetics and Chromatin: Interactions and processes
      11-13 March 2013

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          Abstract

          The X-linked region now known as the 'X-inactivation center' (Xic) was once dominated by protein-coding genes but, with the rise of Eutherian mammals some 150-200 million years ago, became infiltrated by genes that produce long noncoding RNA (lncRNA). Some of the noncoding genes have been shown to play crucial roles during X-chromosome inactivation (XCI), including the targeting of chromatin modifiers to the X. The rapid establishment of lncRNA hints at a possible preference for long transcripts in some aspects of epigenetic regulation. We will consider advantages lncRNA offers in delivering allelic, cis-limited, and locus-specific control. Unlike proteins and small RNAs, long ncRNAs are tethered to the site of transcription, and can therefore tag the allele of origin and mark unique regions in a complex genome. We will discuss general roles of lncRNA, with special consideration of XCI and developmental consequences when Xist RNA is aberrantly expressed. Like small RNAs, lncRNAs may emerge as powerful regulators of the epigenome.

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          Author and article information

          Conference
          Epigenetics Chromatin
          Epigenetics Chromatin
          Epigenetics & Chromatin
          BioMed Central
          1756-8935
          2013
          18 March 2013
          : 6
          : Suppl 1
          : O31
          Affiliations
          [1 ]Howard Hughes Medical Institute, USA
          [2 ]Department of Molecular Biology, Massachusetts General Hospital, USA
          [3 ]Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
          Article
          1756-8935-6-S1-O31
          10.1186/1756-8935-6-S1-O31
          3600807
          41f1a62f-3b3c-490d-ae0c-cac0291cb90b
          Copyright ©2013 Lee; licensee BioMed Central Ltd.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          Epigenetics and Chromatin: Interactions and processes
          Boston, MA, USA
          11-13 March 2013
          History
          Categories
          Oral Presentation

          Genetics
          Genetics

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