Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Dynamic spatiotemporal synaptic integration in cortical neurons: neuronal gain, revisited.

Journal of Neurophysiology

Time Factors, physiology, Synaptic Transmission, Synapses, Probability, methods, Patch-Clamp Techniques, Nonlinear Dynamics, Neurons, Neural Inhibition, Models, Neurological, Membrane Potentials, Ion Channel Gating, Electric Conductivity, cytology, Cerebral Cortex, Animals

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Gain modulation is a ubiquitous phenomenon in cortical neurons, providing flexibility to operate under changing conditions. The prevailing view is that this modulation reflects a change in the relationship between mean input and output firing rate brought about by variation in neuronal membrane characteristics. An alternative mechanism is proposed for neuronal gain modulation that takes into account the capability of cortical neurons to process spatiotemporal synaptic correlations. Through the use of numerical simulations, it is shown that voltage-gated and leak conductances, membrane potential, noise, and input firing rate modify the sensitivity of cortical neurons to the degree of temporal correlation between their synaptic inputs. These changes are expressed in a change of the temporal window for synaptic integration and the range of input correlation over which response probability is graded. The study also demonstrates that temporal integration depends on the distance between the inputs and that this interplay of space and time is modulated by voltage-gated and leak conductances. Thus, gain modulation may reflect a change in the relationship between spatiotemporal synaptic correlations and output firing probability. It is further proposed that by acting synergistically with the network, dynamic spatiotemporal synaptic integration in cortical neurons may serve a functional role in the formation of dynamic cell assemblies.

      Related collections

      Author and article information

      Journal
      10.1152/jn.00542.2005
      15987760

      Comments

      Comment on this article